Literature DB >> 22160469

Role of NYGGF4 in insulin resistance.

Xiaoling Chen1, Zhiqing Huang, Daiwen Chen, Gang Jia, Xiangbing Mao, Xiuqun Wu.   

Abstract

Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin. A major factor in the development of insulin resistance syndrome is obesity. NYGGF4 is a novel gene that is abundantly expressed in the adipose tissue of obese subjects. NYGGF4 induced the secretion of FFAs and TNF-α and caused mitochondrial dysfunction, which may cause insulin resistance. This review will summarize the effect of NYGGF4 on the adipogenesis, glucose uptake and mitochondrial dysfunction in vitro, and the possible mechanism and signal pathway of NYGGF4 for insulin resistance.

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Year:  2011        PMID： 22160469     DOI： 10.1007/s11033-011-1336-7

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  46 in total

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Authors:  B B Kahn; J S Flier
Journal:  J Clin Invest       Date:  2000-08       Impact factor: 14.808

Review 2.  Mitochondria: releasing power for life and unleashing the machineries of death.

Authors:  Donald D Newmeyer; Shelagh Ferguson-Miller
Journal:  Cell       Date:  2003-02-21       Impact factor: 41.582

Review 3.  Critical nodes in signalling pathways: insights into insulin action.

Authors:  Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

4.  Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.

Authors:  Yuji Kajiwara; Sonia Franciosi; Nagahide Takahashi; Lisa Krug; James Schmeidler; Kevin Taddei; Vahram Haroutunian; Ulrik Fried; Michelle Ehrlich; Ralph N Martins; Samuel Gandy; Joseph D Buxbaum
Journal:  Mol Neurodegener       Date:  2010-01-14       Impact factor: 14.195

5.  Superoxide activates mitochondrial uncoupling proteins.

Authors:  Karim S Echtay; Damien Roussel; Julie St-Pierre; Mika B Jekabsons; Susana Cadenas; Jeff A Stuart; James A Harper; Stephen J Roebuck; Alastair Morrison; Susan Pickering; John C Clapham; Martin D Brand
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

6.  Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal.

Authors:  C Selman; J S McLaren; M J Himanka; J R Speakman
Journal:  Free Radic Biol Med       Date:  2000-04-15       Impact factor: 7.376

Review 7.  Insulin receptor signals regulating GLUT4 translocation and actin dynamics.

Authors:  Makoto Kanzaki
Journal:  Endocr J       Date:  2006-05-12       Impact factor: 2.349

8.  Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose.

Authors:  Sébastien Vankoningsloo; Marie Piens; Christophe Lecocq; Audrey Gilson; Aurélia De Pauw; Patricia Renard; Catherine Demazy; Andrée Houbion; Martine Raes; Thierry Arnould
Journal:  J Lipid Res       Date:  2005-03-01       Impact factor: 5.922

Review 9.  Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.

Authors:  Bruce M Spiegelman
Journal:  Novartis Found Symp       Date:  2007

10.  Cloning of a pig glucose transporter 4 cDNA fragment: use in developing a sensitive ribonuclease protection assay for quantifying low-abundance glucose transporter 4 mRNA in porcine adipose tissue.

Authors:  P Y Chiu; S Chaudhuri; P A Harding; J J Kopchick; S Donkin; T D Etherton
Journal:  J Anim Sci       Date:  1994-05       Impact factor: 3.159
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  2 in total

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Journal:  PLoS One       Date:  2019-04-16       Impact factor: 3.240

2.  PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB.

Authors:  Jingying Xu; Xiuhai Ren; Anup Singh Pathania; G Esteban Fernandez; Anthony Tran; Yifu Zhang; Rex A Moats; Gregory M Shackleford; Anat Erdreich-Epstein
Journal:  Sci Rep       Date:  2017-04-11       Impact factor: 4.996
  2 in total

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