STUDY OBJECTIVE: This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis. METHODS: Sixty-seven infants, 2-24 months old and hospitalized with their first episode of acute RSV bronchiolitis, were selected for this study. Eosinophil-active cytokine and chemokine profiles in nasal lavage supernatants taken within the first 48 h of admission were determined by a multiplex bead array system (Luminex). Comparisons were made with control (Control group) subjects (n = 20). RESULTS: Nasal IFN-γ levels were significantly higher (P < 0.0001) in RSV bronchiolitis (median = 4.4 pg/ml) infants compared to controls (0.0 pg/ml). IFN-γ levels correlated significantly with the levels of nasal eotaxin (r = 0.566, P < 0.0001), RANTES (r = 0.627, P < 0.0001), GM-CSF (r = 0.849, P < 0.0001), and EDN (r = 0.693, P < 0.001). Nasal interleukin (IL)-4, IL-5, and IL-13 were below sensitivity levels in most RSV bronchiolitis and control subjects. CONCLUSION: These results suggest that IFN-γ may play an important role in eosinophilic inflammation in RSV bronchiolitis.
STUDY OBJECTIVE: This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis. METHODS: Sixty-seven infants, 2-24 months old and hospitalized with their first episode of acute RSV bronchiolitis, were selected for this study. Eosinophil-active cytokine and chemokine profiles in nasal lavage supernatants taken within the first 48 h of admission were determined by a multiplex bead array system (Luminex). Comparisons were made with control (Control group) subjects (n = 20). RESULTS: Nasal IFN-γ levels were significantly higher (P < 0.0001) in RSV bronchiolitis (median = 4.4 pg/ml) infants compared to controls (0.0 pg/ml). IFN-γ levels correlated significantly with the levels of nasal eotaxin (r = 0.566, P < 0.0001), RANTES (r = 0.627, P < 0.0001), GM-CSF (r = 0.849, P < 0.0001), and EDN (r = 0.693, P < 0.001). Nasal interleukin (IL)-4, IL-5, and IL-13 were below sensitivity levels in most RSV bronchiolitis and control subjects. CONCLUSION: These results suggest that IFN-γ may play an important role in eosinophilic inflammation in RSV bronchiolitis.
Authors: L Bont; C J Heijnen; A Kavelaars; W M van Aalderen; F Brus; J M Draaisma; M Pekelharing-Berghuis; R A van Diemen-Steenvoorde; J L Kimpen Journal: J Infect Dis Date: 2001-06-26 Impact factor: 5.226
Authors: Berkeley L Bennett; Roberto P Garofalo; Stanley G Cron; Yashoda M Hosakote; Robert L Atmar; Charles G Macias; Pedro A Piedra Journal: J Infect Dis Date: 2007-04-12 Impact factor: 5.226
Authors: S M van Schaik; N Obot; G Enhorning; K Hintz; K Gross; G E Hancock; A M Stack; R C Welliver Journal: J Med Virol Date: 2000-10 Impact factor: 2.327
Authors: Maria Pino; David J Kelvin; Jesus F Bermejo-Martin; Ana Alonso; Vanesa Matías; Alberto Tenorio; Lucia Rico; Jose M Eiros; J Castrodeza; Alfredo Blanco-Quiros; Julio Ardura; Raul Ortiz de Lejarazu Journal: Pediatr Allergy Immunol Date: 2009-02-28 Impact factor: 6.377
Authors: María Luz García-García; Cristina Calvo; Ana Moreira; José Antonio Cañas; Francisco Pozo; Beatriz Sastre; Sergio Quevedo; Inmaculada Casas; Victoria Del Pozo Journal: Medicine (Baltimore) Date: 2017-05 Impact factor: 1.889
Authors: Yanaika S Sabogal Piñeros; Suzanne M Bal; Annemiek Dijkhuis; Christof J Majoor; Barbara S Dierdorp; Tamara Dekker; Esmée P Hoefsmit; Peter I Bonta; Daisy Picavet; Nicole N van der Wel; Leo Koenderman; Peter J Sterk; Lara Ravanetti; René Lutter Journal: Allergy Date: 2019-05-15 Impact factor: 13.146
Authors: Heidi Makrinioti; Andrew Bush; James Gern; Sebastian Lennox Johnston; Nikolaos Papadopoulos; Wojciech Feleszko; Carlos A Camargo; Kohei Hasegawa; Tuomas Jartti Journal: Front Immunol Date: 2021-12-03 Impact factor: 7.561