Literature DB >> 22159523

Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review).

Alessandro Martino1, Juan Sainz, Gabriele Buda, Krzysztof Jamroziak, Rui Manuel Reis, Ramón García-Sanz, Manuel Jurado, Rafael Ríos, Zofia Szemraj-Rogucka, Herlander Marques, Fabienne Lesueur, Victor Moreno, Enrico Orciuolo, Federica Gemignani, Stefano Landi, Anna Maria Rossi, Charles Dumontet, Mario Petrini, Daniele Campa, Federico Canzian.   

Abstract

There is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main findings in the genetic susceptibility and pharmacogenetics of MM and present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch) consortium in contributing to determine the role of genetic variation in pharmacogenetics and in MM risk.

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Year:  2011        PMID： 22159523     DOI： 10.3892/ijo.2011.1284

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  5 in total

1.  Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.

Authors:  Elad Ziv; Eric Dean; Donglei Hu; Alessandro Martino; Daniel Serie; Karen Curtin; Daniele Campa; Blake Aftab; Paige Bracci; Gabriele Buda; Yi Zhao; Jennifer Caswell-Jin; Robert Diasio; Charles Dumontet; Marek Dudziński; Laura Fejerman; Alexandra Greenberg; Scott Huntsman; Krzysztof Jamroziak; Artur Jurczyszyn; Shaji Kumar; Djordje Atanackovic; Martha Glenn; Lisa A Cannon-Albright; Brandt Jones; Adam Lee; Herlander Marques; Thomas Martin; Joaquin Martinez-Lopez; Vincent Rajkumar; Juan Sainz; Annette Juul Vangsted; Marzena Wątek; Jeffrey Wolf; Susan Slager; Nicola J Camp; Federico Canzian; Celine Vachon
Journal:  Nat Commun       Date:  2015-07-22       Impact factor: 14.919

2.  A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.

Authors:  Rafael Ríos-Tamayo; Carmen Belén Lupiañez; Daniele Campa; Thomas Hielscher; Niels Weinhold; Joaquin Martínez-López; Andrés Jerez; Stefano Landi; Krzysztof Jamroziak; Charles Dumontet; Marzena Wątek; Fabienne Lesueur; Rui Manuel Reis; Herlander Marques; Artur Jurczyszyn; Ulla Vogel; Gabriele Buda; Ramón García-Sanz; Enrico Orciuolo; Mario Petrini; Annette J Vangsted; Federica Gemignani; Asta Försti; Hartmut Goldschmidt; Kari Hemminki; Federico Canzian; Manuel Jurado; Juan Sainz
Journal:  Oncotarget       Date:  2016-09-13

3.  Genetically determined telomere length and multiple myeloma risk and outcome.

Authors:  Federico Canzian; Daniele Campa; Matteo Giaccherini; Angelica Macauda; Enrico Orciuolo; Marcin Rymko; Karolina Gruenpeter; Charles Dumontet; Malgorzata Raźny; Victor Moreno; Gabriele Buda; Katia Beider; Judit Varkonyi; Hervé Avet-Loiseau; Joaquín Martinez-Lopez; Herlander Marques; Marzena Watek; Maria Eugenia Sarasquete; Vibeke Andersen; Lionel Karlin; Anna Suska; Marcin Kruszewski; Niels Abildgaard; Marek Dudziński; Aleksandra Butrym; Arnold Nagler; Annette Juul Vangsted; Katalin Kadar; Tomczak Waldemar; Krzysztof Jamroziak; Svend Erik Hove Jacobsen; Lene Hyldahl Ebbesen; Michał Taszner; Grzegorz Mazur; Fabienne Lesueur; Matteo Pelosini; Ramon Garcia-Sanz; Artur Jurczyszyn; Delphine Demangel; Rui Manuel Reis; Elżbieta Iskierka-Jażdżewska; Miroslaw Markiewicz; Federica Gemignani; Edyta Subocz; Daria Zawirska; Agnieszka Druzd-Sitek; Anna Stępień; M Henar Alonso; Juan Sainz
Journal:  Blood Cancer J       Date:  2021-04-14       Impact factor: 11.037

4.  A polygenic risk score for multiple myeloma risk prediction.

Authors:  Federico Canzian; Chiara Piredda; Angelica Macauda; Daria Zawirska; Niels Frost Andersen; Arnon Nagler; Jan Maciej Zaucha; Grzegorz Mazur; Charles Dumontet; Marzena Wątek; Krzysztof Jamroziak; Juan Sainz; Judit Várkonyi; Aleksandra Butrym; Katia Beider; Niels Abildgaard; Fabienne Lesueur; Marek Dudziński; Annette Juul Vangsted; Matteo Pelosini; Edyta Subocz; Mario Petrini; Gabriele Buda; Małgorzata Raźny; Federica Gemignani; Herlander Marques; Enrico Orciuolo; Katalin Kadar; Artur Jurczyszyn; Agnieszka Druzd-Sitek; Ulla Vogel; Vibeke Andersen; Rui Manuel Reis; Anna Suska; Hervé Avet-Loiseau; Marcin Kruszewski; Waldemar Tomczak; Marcin Rymko; Stephane Minvielle; Daniele Campa
Journal:  Eur J Hum Genet       Date:  2021-11-30       Impact factor: 4.246

5.  Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.

Authors:  Angelica Macauda; Chiara Piredda; Alyssa I Clay-Gilmour; Juan Sainz; Gabriele Buda; Miroslaw Markiewicz; Torben Barington; Elad Ziv; Michelle A T Hildebrandt; Alem A Belachew; Judit Varkonyi; Witold Prejzner; Agnieszka Druzd-Sitek; John Spinelli; Niels Frost Andersen; Jonathan N Hofmann; Marek Dudziński; Joaquin Martinez-Lopez; Elzbieta Iskierka-Jazdzewska; Roger L Milne; Grzegorz Mazur; Graham G Giles; Lene Hyldahl Ebbesen; Marcin Rymko; Krzysztof Jamroziak; Edyta Subocz; Rui Manuel Reis; Ramon Garcia-Sanz; Anna Suska; Eva Kannik Haastrup; Daria Zawirska; Norbert Grzasko; Annette Juul Vangsted; Charles Dumontet; Marcin Kruszewski; Magdalena Dutka; Nicola J Camp; Rosalie G Waller; Waldemar Tomczak; Matteo Pelosini; Małgorzata Raźny; Herlander Marques; Niels Abildgaard; Marzena Wątek; Artur Jurczyszyn; Elizabeth E Brown; Sonja Berndt; Aleksandra Butrym; Celine M Vachon; Aaron D Norman; Susan L Slager; Federica Gemignani; Federico Canzian; Daniele Campa
Journal:  Int J Cancer       Date:  2021-03-30       Impact factor: 7.396
  5 in total

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