OBJECTIVE: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. DESIGN: Immunohistochemical analysis. SETTING: University hospital. PATIENTS: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. RESULTS: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. CONCLUSION: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease.
OBJECTIVE: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1R132H protein. DESIGN: Immunohistochemical analysis. SETTING: University hospital. PATIENTS: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. RESULTS:Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. CONCLUSION: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease.
Authors: Patrick Y Wen; Michael Weller; Eudocia Quant Lee; Brian M Alexander; Jill S Barnholtz-Sloan; Floris P Barthel; Tracy T Batchelor; Ranjit S Bindra; Susan M Chang; E Antonio Chiocca; Timothy F Cloughesy; John F DeGroot; Evanthia Galanis; Mark R Gilbert; Monika E Hegi; Craig Horbinski; Raymond Y Huang; Andrew B Lassman; Emilie Le Rhun; Michael Lim; Minesh P Mehta; Ingo K Mellinghoff; Giuseppe Minniti; David Nathanson; Michael Platten; Matthias Preusser; Patrick Roth; Marc Sanson; David Schiff; Susan C Short; Martin J B Taphoorn; Joerg-Christian Tonn; Jonathan Tsang; Roel G W Verhaak; Andreas von Deimling; Wolfgang Wick; Gelareh Zadeh; David A Reardon; Kenneth D Aldape; Martin J van den Bent Journal: Neuro Oncol Date: 2020-08-17 Impact factor: 12.300
Authors: Ying Zhuge; Andra V Krauze; Holly Ning; Jason Y Cheng; Barbara C Arora; Kevin Camphausen; Robert W Miller Journal: Med Phys Date: 2017-08-20 Impact factor: 4.071
Authors: Andrea Horváth; Gábor Perlaki; Arnold Tóth; Gergely Orsi; Szilvia Nagy; Tamás Dóczi; Zsolt Horváth; Péter Bogner Journal: J Neurooncol Date: 2015-11-27 Impact factor: 4.130