OBJECTIVE: The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensive rats both submitted and not submitted to fructose overload. METHODS: Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis. RESULTS: The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensive rats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group. CONCLUSIONS: These data suggest that the metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.
OBJECTIVE: The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensiverats both submitted and not submitted to fructose overload. METHODS: Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis. RESULTS: The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensiverats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group. CONCLUSIONS: These data suggest that the metabolic disorders in hypertensiverats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.
Authors: Janaina de O Brito-Monzani; Iris Callado Sanches; Nathalia Bernardes; Kátia Ponciano; Ivana C Moraes-Silva; Maria-Cláudia Irigoyen; Susana Llesuy; Kátia De Angelis Journal: Hypertens Res Date: 2017-11-02 Impact factor: 3.872
Authors: Alexandre M Lehnen; Bruno Rodrigues; Maria Cláudia Irigoyen; Kátia De Angelis; Beatriz D'Agord Schaan Journal: J Diabetes Res Date: 2013-03-14 Impact factor: 4.011
Authors: Jacqueline Freire Machi; Danielle da Silva Dias; Sarah Cristina Freitas; Oscar Albuquerque de Moraes; Maikon Barbosa da Silva; Paula Lázara Cruz; Cristiano Mostarda; Vera M C Salemi; Mariana Morris; Kátia De Angelis; Maria-Cláudia Irigoyen Journal: Clin Interv Aging Date: 2016-03-22 Impact factor: 4.458