Literature DB >> 22156205

Shields up: the Tup1-Cyc8 repressor complex blocks coactivator recruitment.

Emily J Parnell1, David J Stillman.   

Abstract

The Tup1-Cyc8 complex is responsible for repression of a large and diverse collection of genes in Saccharomyces cerevisiae. The predominant view has been that Tup1-Cyc8 functions as a corepressor, actively associating with regulatory proteins and organizing chromatin to block transcription. A new study by Wong and Struhl in this issue of Genes & Development (pp. 2525-2539) challenges nearly 20 years of models by demonstrating that Tup1-Cyc8 functions primarily as a shield to block DNA-binding proteins from recruiting transcriptional coactivators.

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Year:  2011        PMID： 22156205      PMCID： PMC3243054          DOI： 10.1101/gad.181768.111

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  47 in total

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Authors:  L Huang; W Zhang; S Y Roth
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

Review 2.  Transcriptional repression by Tup1-Ssn6.

Authors:  Tania M Malavé; Sharon Y R Dent
Journal:  Biochem Cell Biol       Date:  2006-08       Impact factor: 3.626

3.  A chromatin-mediated mechanism for specification of conditional transcription factor targets.

Authors:  Michael J Buck; Jason D Lieb
Journal:  Nat Genet       Date:  2006-11-12       Impact factor: 38.330

4.  Exploring the metabolic and genetic control of gene expression on a genomic scale.

Authors:  J L DeRisi; V R Iyer; P O Brown
Journal:  Science       Date:  1997-10-24       Impact factor: 47.728

5.  The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae.

Authors:  T Mizuno; N Nakazawa; P Remgsamrarn; T Kunoh; Y Oshima; S Harashima
Journal:  Curr Genet       Date:  1998-04       Impact factor: 3.886

6.  Effect of sequence-directed nucleosome disruption on cell-type-specific repression by alpha2/Mcm1 in the yeast genome.

Authors:  Nobuyuki Morohashi; Yuichi Yamamoto; Shunsuke Kuwana; Wataru Morita; Heisaburo Shindo; Aaron P Mitchell; Mitsuhiro Shimizu
Journal:  Eukaryot Cell       Date:  2006-09-15

Review 7.  The yeast Mediator complex and its regulation.

Authors:  Stefan Björklund; Claes M Gustafsson
Journal:  Trends Biochem Sci       Date:  2005-05       Impact factor: 13.807

8.  Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism.

Authors:  Zhengjian Zhang; Joseph C Reese
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

9.  The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes.

Authors:  Hirohito Haruki; Junichi Nishikawa; Ulrich K Laemmli
Journal:  Mol Cell       Date:  2008-09-26       Impact factor: 17.970

10.  Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene.

Authors:  Alastair B Fleming; Sari Pennings
Journal:  Nucleic Acids Res       Date:  2007-08-17       Impact factor: 16.971
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  7 in total

1.  Acquisition of the ability to assimilate mannitol by Saccharomyces cerevisiae through dysfunction of the general corepressor Tup1-Cyc8.

Authors:  Moeko Chujo; Shiori Yoshida; Anri Ota; Kousaku Murata; Shigeyuki Kawai
Journal:  Appl Environ Microbiol       Date:  2014-10-10       Impact factor: 4.792

2.  The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes.

Authors:  Alberto Elías-Villalobos; Alfonso Fernández-Álvarez; Ismael Moreno-Sánchez; Dominique Helmlinger; José I Ibeas
Journal:  PLoS Pathog       Date:  2015-08-28       Impact factor: 6.823

3.  On the Mechanism of Gene Silencing in Saccharomyces cerevisiae.

Authors:  David Lee Steakley; Jasper Rine
Journal:  G3 (Bethesda)       Date:  2015-06-16       Impact factor: 3.154

4.  The transcriptional repressor TupA in Aspergillus niger is involved in controlling gene expression related to cell wall biosynthesis, development, and nitrogen source availability.

Authors:  Doreen Schachtschabel; Mark Arentshorst; Benjamin M Nitsche; Sam Morris; Kristian F Nielsen; Cees A M J J van den Hondel; Frans M Klis; Arthur F J Ram
Journal:  PLoS One       Date:  2013-10-29       Impact factor: 3.240

5.  Functional analysis of the global repressor Tup1 for maltose metabolism in Saccharomyces cerevisiae: different roles of the functional domains.

Authors:  Xue Lin; Ai-Qun Yu; Cui-Ying Zhang; Li Pi; Xiao-Wen Bai; Dong-Guang Xiao
Journal:  Microb Cell Fact       Date:  2017-11-09       Impact factor: 5.328

6.  Regulated repression governs the cell fate promoter controlling yeast meiosis.

Authors:  Janis Tam; Folkert J van Werven
Journal:  Nat Commun       Date:  2020-05-08       Impact factor: 14.919

7.  Convergence between Regulation of Carbon Utilization and Catabolic Repression in Xanthophyllomyces dendrorhous.

Authors:  Pilar Martinez-Moya; Sebastián Campusano; Pamela Córdova; Alberto Paradela; Dionisia Sepulveda; Jennifer Alcaíno; Marcelo Baeza; Víctor Cifuentes
Journal:  mSphere       Date:  2020-04-01       Impact factor: 4.389
  7 in total

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