OBJECTIVES: To evaluate a two-tier reflex guaiac-based faecal occult blood test (gFOBT)/faecal immunochemical test (FIT) algorithm in screening for colorectal cancer. SETTING: Fourth screening round in NHS Tayside (Scotland). METHODS: gFOBT were sent to 50-74-year-olds. Participants with five or six windows positive were offered colonoscopy. Participants with one to four windows positive were sent a FIT and, if positive, were offered colonoscopy. Participants providing an untestable gFOBT were sent a FIT and, if positive, were offered colonoscopy. Outcomes following positive results, cancer stages and key performance indicators were assessed. RESULTS: Of 131,885 invited, 73,315 (55.6%) responded. There were 66,957 (91.3%) negative, 241 (0.3%) strong positive, 5230 (7.1%) weak positive and 887 (1.2%) untestable results. The 241 participants who had five or six windows positive had more cancers than those positive by other routes: only 3 of the 30 cancers (9.7%) were Dukes' A. Among the 983 positive results from the weak positive gFOBT then positive FIT route, there were fewer cancers and more normal colonoscopies, but more adenomas than in the group with a strong positive gFOBT. In those with an untestable gFOBT, 77 had a positive FIT result, with fewer true and more false positive results than in the other groups. Fewer males had cancer and stages were earlier than in females, but more had adenoma. The detection rate for cancer was 0.18% and the PPV for cancer and all adenomas was 41.3%. CONCLUSIONS: The algorithm and FIT following a weak positive gFOBT have advantages. FIT following an untestable gFOBT warrants review.
OBJECTIVES: To evaluate a two-tier reflex guaiac-based faecal occult blood test (gFOBT)/faecal immunochemical test (FIT) algorithm in screening for colorectal cancer. SETTING: Fourth screening round in NHS Tayside (Scotland). METHODS:gFOBT were sent to 50-74-year-olds. Participants with five or six windows positive were offered colonoscopy. Participants with one to four windows positive were sent a FIT and, if positive, were offered colonoscopy. Participants providing an untestable gFOBT were sent a FIT and, if positive, were offered colonoscopy. Outcomes following positive results, cancer stages and key performance indicators were assessed. RESULTS: Of 131,885 invited, 73,315 (55.6%) responded. There were 66,957 (91.3%) negative, 241 (0.3%) strong positive, 5230 (7.1%) weak positive and 887 (1.2%) untestable results. The 241 participants who had five or six windows positive had more cancers than those positive by other routes: only 3 of the 30 cancers (9.7%) were Dukes' A. Among the 983 positive results from the weak positive gFOBT then positive FIT route, there were fewer cancers and more normal colonoscopies, but more adenomas than in the group with a strong positive gFOBT. In those with an untestable gFOBT, 77 had a positive FIT result, with fewer true and more false positive results than in the other groups. Fewer males had cancer and stages were earlier than in females, but more had adenoma. The detection rate for cancer was 0.18% and the PPV for cancer and all adenomas was 41.3%. CONCLUSIONS: The algorithm and FIT following a weak positive gFOBT have advantages. FIT following an untestable gFOBT warrants review.
Authors: Stephen T McSorley; Mark Johnstone; Colin W Steele; Campbell S D Roxburgh; Paul G Horgan; Donald C McMillan; David Mansouri Journal: Int J Colorectal Dis Date: 2018-12-04 Impact factor: 2.571
Authors: Robert Jc Steele; Greig Stanners; Jaroslaw Lang; David H Brewster; Francis A Carey; Callum G Fraser Journal: United European Gastroenterol J Date: 2016-01-06 Impact factor: 4.623
Authors: Graeme P Young; Erin L Symonds; James E Allison; Stephen R Cole; Callum G Fraser; Stephen P Halloran; Ernst J Kuipers; Helen E Seaman Journal: Dig Dis Sci Date: 2014-12-10 Impact factor: 3.199
Authors: Benjamin Kearns; Sophie Whyte; Helen E Seaman; Julia Snowball; Stephen P Halloran; Piers Butler; Julietta Patnick; Claire Nickerson; Jim Chilcott Journal: Br J Cancer Date: 2016-01-14 Impact factor: 7.640
Authors: Gavin Rc Clark; Annie S Anderson; Thomas G Godfrey; Judith A Strachan; Callum G Fraser; Robert Jc Steele Journal: BMJ Open Date: 2020-09-22 Impact factor: 2.692
Authors: Robert Jc Steele; Paula J McDonald; Jayne Digby; Linda Brownlee; Judith A Strachan; Gillian Libby; Paula L McClements; Janice Birrell; Francis A Carey; Robert H Diament; Margaret Balsitis; Callum G Fraser Journal: United European Gastroenterol J Date: 2013-06 Impact factor: 4.623