BACKGROUND: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). METHODS: One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. RESULTS: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P=0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P=0.046). CONCLUSION: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
BACKGROUND: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). METHODS: One hundred and six OCDpatients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. RESULTS: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P=0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P=0.046). CONCLUSION: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
Authors: Omer Linkovski; Michael G Wheaton; Jordana Zwerling; Zagaa Odgerel; Peter van Roessel; Maria Filippou-Frye; Anthony Lombardi; Brianna Wright; Shari A Steinman; Helen Blair Simpson; Francis Lee; Carolyn I Rodriguez Journal: J Clin Psychopharmacol Date: 2019 Jan/Feb Impact factor: 3.153
Authors: Tina B Lonsdorf; Armita Golkar; Kara M Lindström; Jan Haaker; Arne Öhman; Martin Schalling; Martin Ingvar Journal: Soc Cogn Affect Neurosci Date: 2014-08-07 Impact factor: 3.436
Authors: Helen B Simpson; Edna B Foa; Michael G Wheaton; Thea Gallagher; Marina Gershkovich; Andrew B Schmidt; Jonathan D Huppert; Raphael B Campeas; Patricia A Imms; Shawn P Cahill; Christina DiChiara; Steven D Tsao; Anthony C Puliafico; Daniel Chazin; Anu Asnaani; Kelly Moore; Jeremy Tyler; Shari A Steinman; Arturo Sanchez-LaCay; Sandy Capaldi; Ivar Snorrason; Elizabeth Turk-Karan; Donna Vermes; Eyal Kalanthroff; Anthony Pinto; Chang-Gyu Hahn; Bin Xu; Page E Van Meter; Martha Katechis; Jennifer Scodes; Yuanjia Wang Journal: Behav Res Ther Date: 2021-05-29
Authors: J M Bakker; R Lieverse; C Menne-Lothmann; W Viechtbauer; E Pishva; G Kenis; N Geschwind; F Peeters; J van Os; M Wichers Journal: Transl Psychiatry Date: 2014-04-22 Impact factor: 6.222
Authors: Fabricio H Do-Monte; Jose Rodriguez-Romaguera; Luis E Rosas-Vidal; Gregory J Quirk Journal: Front Behav Neurosci Date: 2013-08-08 Impact factor: 3.558