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Literature DB >> 22152471

Regulation of ribonucleotide reductase during iron limitation.

Alexandra Seguin¹, Diane McVey Ward, Jerry Kaplan.

Abstract

In this issue of Molecular Cell, Sanvisens et al. (2011) report a new mechanism for regulation of yeast ribonucleotide reductase activity that occurs during iron deprivation.

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 22152471 PMCID： PMC3259026 DOI： 10.1016/j.molcel.2011.11.011

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.

Authors: Yan Zhang; Lili Liu; Xiaorong Wu; Xiuxiang An; JoAnne Stubbe; Mingxia Huang
Journal: J Biol Chem Date: 2011-09-19 Impact factor: 5.157

2. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.

Authors: Zhen Zhang; Xiuxiang An; Kui Yang; Deborah L Perlstein; Leslie Hicks; Neil Kelleher; JoAnne Stubbe; Mingxia Huang
Journal: Proc Natl Acad Sci U S A Date: 2006-01-23 Impact factor: 11.205

3. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.

Authors: X Zhao; A Chabes; V Domkin; L Thelander; R Rothstein
Journal: EMBO J Date: 2001-07-02 Impact factor: 11.598

3 in total

Review 1. Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation.

Authors: Sabeeha S Merchant; John D Helmann
Journal: Adv Microb Physiol Date: 2012 Impact factor: 3.517

2. Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells.

Authors: Gamini Siriwardana; Paul A Seligman
Journal: Physiol Rep Date: 2015-03

3. Two cell cycle blocks caused by iron chelation of neuroblastoma cells: separating cell cycle events associated with each block.

Authors: Gamini Siriwardana; Paul A Seligman
Journal: Physiol Rep Date: 2013-12-06

3 in total

Regulation of ribonucleotide reductase during iron limitation.

1. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.

2. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.

3. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.

4. Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.

5. Metabolic response to iron deficiency in Saccharomyces cerevisiae.

Review 6. Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo.

7. Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.

8. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.

9. Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators.

10. Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit.

Review 1. Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation.

2. Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells.

3. Two cell cycle blocks caused by iron chelation of neuroblastoma cells: separating cell cycle events associated with each block.