Marius George Linguraru1, Neil Panjwani, Joel G Fletcher, Ronald M Summers. 1. Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. mglinguraru@gmail.com
Abstract
PURPOSE: To evaluate the performance of a computer-aided detection (CAD) system for detecting colonic polyps at noncathartic computed tomography colonography (CTC) in conjunction with an automated image-based colon cleansing algorithm. METHODS: An automated colon cleansing algorithm was designed to detect and subtract tagged-stool, accounting for heterogeneity and poor tagging, to be used in conjunction with a colon CAD system. The method is locally adaptive and combines intensity, shape, and texture analysis with probabilistic optimization. CTC data from cathartic-free bowel preparation were acquired for testing and training the parameters. Patients underwent various colonic preparations with barium or Gastroview in divided doses over 48 h before scanning. No laxatives were administered and no dietary modifications were required. Cases were selected from a polyp-enriched cohort and included scans in which at least 90% of the solid stool was visually estimated to be tagged and each colonic segment was distended in either the prone or supine view. The CAD system was run comparatively with and without the stool subtraction algorithm. RESULTS: The dataset comprised 38 CTC scans from prone and/or supine scans of 19 patients containing 44 polyps larger than 10 mm (22 unique polyps, if matched between prone and supine scans). The results are robust on fine details around folds, thin-stool linings on the colonic wall, near polyps and in large fluid/stool pools. The sensitivity of the CAD system is 70.5% per polyp at a rate of 5.75 false positives/scan without using the stool subtraction module. This detection improved significantly (p = 0.009) after automated colon cleansing on cathartic-free data to 86.4% true positive rate at 5.75 false positives/scan. CONCLUSIONS: An automated image-based colon cleansing algorithm designed to overcome the challenges of the noncathartic colon significantly improves the sensitivity of colon CAD by approximately 15%.
PURPOSE: To evaluate the performance of a computer-aided detection (CAD) system for detecting colonic polyps at noncathartic computed tomography colonography (CTC) in conjunction with an automated image-based colon cleansing algorithm. METHODS: An automated colon cleansing algorithm was designed to detect and subtract tagged-stool, accounting for heterogeneity and poor tagging, to be used in conjunction with a colon CAD system. The method is locally adaptive and combines intensity, shape, and texture analysis with probabilistic optimization. CTC data from cathartic-free bowel preparation were acquired for testing and training the parameters. Patients underwent various colonic preparations with barium or Gastroview in divided doses over 48 h before scanning. No laxatives were administered and no dietary modifications were required. Cases were selected from a polyp-enriched cohort and included scans in which at least 90% of the solid stool was visually estimated to be tagged and each colonic segment was distended in either the prone or supine view. The CAD system was run comparatively with and without the stool subtraction algorithm. RESULTS: The dataset comprised 38 CTC scans from prone and/or supine scans of 19 patients containing 44 polyps larger than 10 mm (22 unique polyps, if matched between prone and supine scans). The results are robust on fine details around folds, thin-stool linings on the colonic wall, near polyps and in large fluid/stool pools. The sensitivity of the CAD system is 70.5% per polyp at a rate of 5.75 false positives/scan without using the stool subtraction module. This detection improved significantly (p = 0.009) after automated colon cleansing on cathartic-free data to 86.4% true positive rate at 5.75 false positives/scan. CONCLUSIONS: An automated image-based colon cleansing algorithm designed to overcome the challenges of the noncathartic colon significantly improves the sensitivity of colon CAD by approximately 15%.
Authors: Iwo W O Serlie; Frans M Vos; Roel Truyen; Frits H Post; Jaap Stoker; Lucas J van Vliet Journal: IEEE Trans Biomed Eng Date: 2010-02-17 Impact factor: 4.538
Authors: Wenli Cai; Hiroyuki Yoshida; Michael E Zalis; Janne Johannes Näppi; Gordon J Harris Journal: Radiographics Date: 2010-03-10 Impact factor: 5.333
Authors: D Heresbach; M Djabbari; F Riou; C Marcus; A Le Sidaner; M A Pierredon-Foulogne; T Ponchon; M Boudiaf; J A Seyrig; H Laumonier; D Luet; M Giraud-Cohen; A L Pelletier; A Charachon; F Ramaholimihaso; P Bouillet; M Veyrac; S Ficarelli; K Vahedi; J Keruhel; H Lamouliatte; C Ridereau-Zins; Y Bouhnik; M Tissier; B Diris; A M Zagdanski; J M Josselin; S Hamonic; Y Gandon Journal: Gut Date: 2011-01-25 Impact factor: 23.059
Authors: Vincent F van Ravesteijn; Cees van Wijk; Frans M Vos; Roel Truyen; Joost F Peters; Jaap Stoker; Lucas J van Vliet Journal: IEEE Trans Med Imaging Date: 2009-08-07 Impact factor: 10.048
Authors: Abraham H Dachman; Nancy A Obuchowski; Jeffrey W Hoffmeister; J Louis Hinshaw; Michael I Frew; Thomas C Winter; Robert L Van Uitert; Senthil Periaswamy; Ronald M Summers; Bruce J Hillman Journal: Radiology Date: 2010-07-27 Impact factor: 11.105