Literature DB >> 22149630

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients.

David J Moser1, Laura L Boles Ponto, Ivy N Miller, Susan K Schultz, Yusuf Menda, Stephan Arndt, Peggy C Nopoulos.   

Abstract

This study was designed to determine the relationships between positron emission tomography (PET)-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular function would be significantly associated with neuropsychological functioning. Results showed that both baseline global cerebral blood flow and cerebrovascular reserve were significantly associated with global neuropsychological functioning, when controlling for age and sex. Cerebrovascular reserve was additionally associated with performance on measures of memory and attention. Additional research is needed to determine whether measures of cerebral blood flow can be used to predict cognitive decline.

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Year:  2011        PMID: 22149630      PMCID: PMC3582376          DOI: 10.1080/13803395.2011.630653

Source DB:  PubMed          Journal:  J Clin Exp Neuropsychol        ISSN: 1380-3395            Impact factor:   2.475


  13 in total

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