Literature DB >> 22149091

Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.

Jörg Ellinger1, Philip Kahl, Johannes von der Gathen, Lukas C Heukamp, Ines Gütgemann, Bernhard Walter, Ferdinand Hofstädter, Patrick J Bastian, Alexander von Ruecker, Stefan C Müller, Sebastian Rogenhofer.   

Abstract

Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.

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Year:  2011        PMID： 22149091     DOI： 10.3109/07357907.2011.636117

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  21 in total

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Authors:  Ashley Kramer; Grant A Challen
Journal:  Semin Hematol       Date:  2016-10-24       Impact factor: 3.851

2.  Histone modifications and cancer: biomarkers of prognosis?

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Journal:  Am J Cancer Res       Date:  2012-08-20       Impact factor: 6.166

3.  Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

Authors:  Wenji Li; Zheng-Yuan Su; Yue Guo; Chengyue Zhang; Renyi Wu; Linbo Gao; Xi Zheng; Zhi-Yun Du; Kun Zhang; Ah-Ng Kong
Journal:  Chem Res Toxicol       Date:  2018-01-08       Impact factor: 3.739

Review 4.  The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

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Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

5.  The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers.

Authors:  Woo Kyun Bae; Kyung Hyun Yoo; Ji Shin Lee; Young Kim; Ik-Joo Chung; Min Ho Park; Jung Han Yoon; Priscilla A Furth; Lothar Hennighausen
Journal:  Mol Carcinog       Date:  2014-07-07       Impact factor: 4.784

6.  SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.

Authors:  W Lu; S Liu; B Li; Y Xie; M G Izban; B R Ballard; S A Sathyanarayana; S E Adunyah; R J Matusik; Z Chen
Journal:  Oncogene       Date:  2016-11-21       Impact factor: 9.867

Review 7.  Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.

Authors:  Xuejiao Tian; Saiyang Zhang; Hong-Min Liu; Yan-Bing Zhang; Christopher A Blair; Dan Mercola; Paolo Sassone-Corsi; Xiaolin Zi
Journal:  Curr Cancer Drug Targets       Date:  2013-06       Impact factor: 3.428

8.  Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes.

Authors:  Kalaivani Kalamohan; Jayaprakash Periasamy; Divya Bhaskar Rao; Georgina D Barnabas; Srigayatri Ponnaiyan; Kumaresan Ganesan
Journal:  Mol Oncol       Date:  2014-05-09       Impact factor: 6.603

9.  Alterations of global histone H4K20 methylation during prostate carcinogenesis.

Authors:  Turang E Behbahani; Philip Kahl; Johannes von der Gathen; Lukas C Heukamp; Claudia Baumann; Ines Gütgemann; Bernhard Walter; Ferdinand Hofstädter; Patrick J Bastian; Alexander von Ruecker; Stefan C Müller; Sebastian Rogenhofer; Jörg Ellinger
Journal:  BMC Urol       Date:  2012-03-13       Impact factor: 2.264

Review 10.  Epigenetic Editing in Prostate Cancer: Challenges and Opportunities.

Authors:  Mariana Brütt Pacheco; Vânia Camilo; Rui Henrique; Carmen Jerónimo
Journal:  Epigenetics       Date:  2021-06-15       Impact factor: 4.861
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