Literature DB >> 22148349

Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.

Yi Sun1, Kentaro Takada, Yasushi Takemoto, Minoru Yoshida, Yuichi Nogi, Shigeru Okada, Shigeki Matsunaga.   

Abstract

Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites, bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin (1) and 6-deoxy-5a,6-didehydrogliotoxin (2), and five known metabolites (3-7). The structures of the new compounds were elucidated by analysis of spectroscopic data and the application of the modified Mosher's analysis. All of the compounds exhibited cytotoxic activity, whereas compounds containing a disulfide bond showed potent inhibitory activity against histone methyltransferase (HMT) G9a. None of them inhibited HMT SET7/9.

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Year:  2011        PMID： 22148349     DOI： 10.1021/np200740e

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  22 in total

1.  A phenotypic screening approach to identify anticancer compounds derived from marine fungi.

Authors:  Bernhard Ellinger; Johanna Silber; Anjali Prashar; Johannes Landskron; Jonas Weber; Sarah Rehermann; Franz-Josef Müller; Stephen Smith; Stephen Wrigley; Kjetil Taskén; Philip Gribbon; Antje Labes; Johannes F Imhoff
Journal:  Assay Drug Dev Technol       Date:  2014-04       Impact factor: 1.738

2.  A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.

Authors:  Bo Li; Ry R Forseth; Albert A Bowers; Frank C Schroeder; Christopher T Walsh
Journal:  Chembiochem       Date:  2012-10-24       Impact factor: 3.164

Review 3.  Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.

Authors:  Xuejiao Tian; Saiyang Zhang; Hong-Min Liu; Yan-Bing Zhang; Christopher A Blair; Dan Mercola; Paolo Sassone-Corsi; Xiaolin Zi
Journal:  Curr Cancer Drug Targets       Date:  2013-06       Impact factor: 3.428

4.  Integration of In Silico and In Vitro Analysis of Gliotoxin Production Reveals a Narrow Range of Producing Fungal Species.

Authors:  Sergio Redrado; Patricia Esteban; María Pilar Domingo; Concepción Lopez; Antonio Rezusta; Ariel Ramirez-Labrada; Maykel Arias; Julián Pardo; Eva M Galvez
Journal:  J Fungi (Basel)       Date:  2022-03-31

Review 5.  Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?

Authors:  Nelson G M Gomes; Florence Lefranc; Anake Kijjoa; Robert Kiss
Journal:  Mar Drugs       Date:  2015-06-19       Impact factor: 5.118

6.  New polyphenols from a deep sea Spiromastix sp. Fungus, and their antibacterial activities.

Authors:  Siwen Niu; Dong Liu; Peter Proksch; Zongze Shao; Wenhan Lin
Journal:  Mar Drugs       Date:  2015-04-22       Impact factor: 5.118

Review 7.  A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Authors:  Yan-Ting Wang; Ya-Rong Xue; Chang-Hong Liu
Journal:  Mar Drugs       Date:  2015-07-23       Impact factor: 5.118

Review 8.  Marine Indole Alkaloids.

Authors:  Natalie Netz; Till Opatz
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118

Review 9.  Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery.

Authors:  Jin-Young Lee; Barbora Orlikova; Marc Diederich
Journal:  Mar Drugs       Date:  2015-08-07       Impact factor: 5.118

Review 10.  Marine low molecular weight natural products as potential cancer preventive compounds.

Authors:  Valentin A Stonik; Sergey N Fedorov
Journal:  Mar Drugs       Date:  2014-01-27       Impact factor: 5.118
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