Literature DB >> 22145602

Salinomycin: a new cancer drug candidate.

Adam Huczynski1.   

Abstract

Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
© 2011 John Wiley & Sons A/S.

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Year:  2012        PMID： 22145602     DOI： 10.1111/j.1747-0285.2011.01287.x

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  27 in total

1.  Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin.

Authors:  Masaya Kai; Noriko Kanaya; Shang V Wu; Carlos Mendez; Duc Nguyen; Thehang Luu; Shiuan Chen
Journal:  Breast Cancer Res Treat       Date:  2015-04-23       Impact factor: 4.872

2.  Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells.

Authors:  Wenyan Lu; Yonghe Li
Journal:  J Cell Biochem       Date:  2014-10       Impact factor: 4.429

3.  Salinomycin and other polyether ionophores are a new class of antiscarring agent.

Authors:  Collynn F Woeller; Charles W O'Loughlin; Elisa Roztocil; Steven E Feldon; Richard P Phipps
Journal:  J Biol Chem       Date:  2014-12-23       Impact factor: 5.157

4.  Salinomycin Suppresses PDGFRβ, MYC, and Notch Signaling in Human Medulloblastoma.

Authors:  Shuang Zhou; Fengfei Wang; Ying Zhang; Max R Johnson; Steven Qian; Min Wu; Erxi Wu
Journal:  Austin J Pharmacol Ther       Date:  2014

5.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

6.  Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.

Authors:  Maria Szkudlarek-Mikho; Rudel A Saunders; Sook Fan Yap; Yun Fong Ngeow; Khew-Voon Chin
Journal:  Biochem Biophys Res Commun       Date:  2012-10-31       Impact factor: 3.575

Review 7.  Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.

Authors:  Yonghe Li; Pui-Kai Li; Michael J Roberts; Rebecca C Arend; Rajeev S Samant; Donald J Buchsbaum
Journal:  Cancer Lett       Date:  2014-04-13       Impact factor: 8.679

Review 8.  Salinomycin: a novel anti-cancer agent with known anti-coccidial activities.

Authors:  Shuang Zhou; Fengfei Wang; Eric T Wong; Ekokobe Fonkem; Tze-Chen Hsieh; Joseph M Wu; Erxi Wu
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

9.  Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1.

Authors:  Kholoud Arafat; Rabah Iratni; Takashi Takahashi; Khatija Parekh; Yusra Al Dhaheri; Thomas E Adrian; Samir Attoub
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240

10.  Lower salinomycin concentration increases apoptotic detachment in high-density cancer cells.

Authors:  Ju-Hwa Kim; Tae Young Kim; Hyung Sik Kim; Suntaek Hong; Sungpil Yoon
Journal:  Int J Mol Sci       Date:  2012-10-12       Impact factor: 5.923
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