OBJECTIVE: Several studies have associated urachal carcinoma with a poor prognosis, because the disease tends to be detected later as the patient is asymptomatic, there are few therapeutic options, and it has a high local recurrence rate. We review our experience with urachal carcinoma and discuss the role of surgical management and chemotherapeutic options. PATIENTS AND METHODS: We reviewed the records of 10 cases with urachal carcinoma evaluated at Keio University Hospital from 1998 to 2009, and examine the surgical and chemotherapeutic options in the management of urachal carcinoma. RESULTS: Median age was 55.0 years. Applying the TNM staging system, 1 case was in stage I, 4 cases in stage II, 4 cases in stage III, and 1 case was in stage IV. Nine cases were managed initially with surgery; 5 by partial cystectomy and 4 by total cystectomy. The median follow-up period was 3.5 years and the survival rate at 2 years was 87.5%. Six of the resected cases remain disease-free. Salvage chemotherapy was performed in 3 cases, and adjuvant chemotherapy was performed in 2 cases. CONCLUSIONS: We had 10 cases with urachal carcinoma. While there is still no standard chemotherapy combination, CPT-11 plus TS-1 produced stable disease in 1 case.
OBJECTIVE: Several studies have associated urachal carcinoma with a poor prognosis, because the disease tends to be detected later as the patient is asymptomatic, there are few therapeutic options, and it has a high local recurrence rate. We review our experience with urachal carcinoma and discuss the role of surgical management and chemotherapeutic options. PATIENTS AND METHODS: We reviewed the records of 10 cases with urachal carcinoma evaluated at Keio University Hospital from 1998 to 2009, and examine the surgical and chemotherapeutic options in the management of urachal carcinoma. RESULTS: Median age was 55.0 years. Applying the TNM staging system, 1 case was in stage I, 4 cases in stage II, 4 cases in stage III, and 1 case was in stage IV. Nine cases were managed initially with surgery; 5 by partial cystectomy and 4 by total cystectomy. The median follow-up period was 3.5 years and the survival rate at 2 years was 87.5%. Six of the resected cases remain disease-free. Salvage chemotherapy was performed in 3 cases, and adjuvant chemotherapy was performed in 2 cases. CONCLUSIONS: We had 10 cases with urachal carcinoma. While there is still no standard chemotherapy combination, CPT-11 plus TS-1 produced stable disease in 1 case.
Authors: Radomir Kosanovic; Rey J Romero; Jonathan K Arad; Michelle Gallas; Rupa Seetharamaiah; Anthony M Gonzalez Journal: J Robot Surg Date: 2013-06-11
Authors: In Kyong Kim; Joo Yong Lee; Jong Kyou Kwon; Jae Joon Park; Kang Su Cho; Won Sik Ham; Sung Joon Hong; Seung Choul Yang; Young Deuk Choi Journal: Korean J Urol Date: 2014-09-05
Authors: Rami Mäkelä; Antti Arjonen; Ville Härmä; Nina Rintanen; Lauri Paasonen; Tobias Paprotka; Kerstin Rönsch; Teijo Kuopio; Juha Kononen; Juha K Rantala Journal: BMC Cancer Date: 2020-06-23 Impact factor: 4.430
Authors: Henning Reis; Ulrich Krafft; Christian Niedworok; Orsolya Módos; Thomas Herold; Mark Behrendt; Hikmat Al-Ahmadie; Boris Hadaschik; Peter Nyirady; Tibor Szarvas Journal: Dis Markers Date: 2018-03-12 Impact factor: 3.434