Literature DB >> 22142244

A vision for a biomedical cloud.

R L Grossman1, K P White.   

Abstract

We present a vision for a Biomedical Cloud that draws on progress in the fields of Genomics, Systems Biology and biomedical data mining. The successful fusion of these areas will combine the use of biomarkers, genetic variants, and environmental variables to build predictive models that will drastically increase the specificity and timeliness of diagnosis for a wide range of common diseases, whilst delivering accurate predictions about the efficacy of treatment options. However, the amount of data being generated by each of these fields is staggering, as is the task of managing and analysing it. Adequate computing infrastructure needs to be developed to assemble, manage and mine the enormous and rapidly growing corpus of 'omics' data along with clinical information. We have now arrived at an intersection point between genome technology, cloud computing and biological data mining. This intersection point provides a launch pad for developing a globally applicable cloud computing platform capable of supporting a new paradigm of data intensive, cloud-enabled predictive medicine.
© 2011 The Association for the Publication of the Journal of Internal Medicine.

Entities:  

Mesh:

Year:  2012        PMID: 22142244      PMCID: PMC6338328          DOI: 10.1111/j.1365-2796.2011.02491.x

Source DB:  PubMed          Journal:  J Intern Med        ISSN: 0954-6820            Impact factor:   8.989


  34 in total

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Authors:  T Ideker; T Galitski; L Hood
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2.  Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.

Authors:  T Ideker; V Thorsson; J A Ranish; R Christmas; J Buhler; J K Eng; R Bumgarner; D R Goodlett; R Aebersold; L Hood
Journal:  Science       Date:  2001-05-04       Impact factor: 47.728

3.  Genetical implications of the structure of deoxyribonucleic acid.

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Journal:  Nature       Date:  1953-05-30       Impact factor: 49.962

4.  Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.

Authors:  J D WATSON; F H CRICK
Journal:  Nature       Date:  1953-04-25       Impact factor: 49.962

5.  Dynamic control of positional information in the early Drosophila embryo.

Authors:  Johannes Jaeger; Svetlana Surkova; Maxim Blagov; Hilde Janssens; David Kosman; Konstantin N Kozlov; Ekaterina Myasnikova; Carlos E Vanario-Alonso; Maria Samsonova; David H Sharp; John Reinitz
Journal:  Nature       Date:  2004-07-15       Impact factor: 49.962

6.  From molecular noise to behavioural variability in a single bacterium.

Authors:  Ekaterina Korobkova; Thierry Emonet; Jose M G Vilar; Thomas S Shimizu; Philippe Cluzel
Journal:  Nature       Date:  2004-04-01       Impact factor: 49.962

7.  An integrative genomics approach to infer causal associations between gene expression and disease.

Authors:  Eric E Schadt; John Lamb; Xia Yang; Jun Zhu; Steve Edwards; Debraj Guhathakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
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8.  A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Authors:  Richard B Jones; Andrew Gordus; Jordan A Krall; Gavin MacBeath
Journal:  Nature       Date:  2005-11-06       Impact factor: 49.962

9.  Genetic dissection of transcriptional regulation in budding yeast.

Authors:  Rachel B Brem; Gaël Yvert; Rebecca Clinton; Leonid Kruglyak
Journal:  Science       Date:  2002-03-28       Impact factor: 47.728

10.  Genetic analysis of genome-wide variation in human gene expression.

Authors:  Michael Morley; Cliona M Molony; Teresa M Weber; James L Devlin; Kathryn G Ewens; Richard S Spielman; Vivian G Cheung
Journal:  Nature       Date:  2004-07-21       Impact factor: 49.962

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  13 in total

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2.  Big data and biomedical informatics: a challenging opportunity.

Authors:  R Bellazzi
Journal:  Yearb Med Inform       Date:  2014-05-22

3.  Genetic simulation tools for post-genome wide association studies of complex diseases.

Authors:  Huann-Sheng Chen; Carolyn M Hutter; Leah E Mechanic; Elizabeth M Gillanders; Eric J Feuer; Christopher I Amos; Vineet Bafna; Elizabeth R Hauser; Ryan D Hernandez; Chun Li; David A Liberles; Kimberly McAllister; Jason H Moore; Dina N Paltoo; George J Papanicolaou; Bo Peng; Marylyn D Ritchie; Gabriel Rosenfeld; John S Witte
Journal:  Genet Epidemiol       Date:  2014-11-04       Impact factor: 2.135

4.  The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools.

Authors:  Ivo D Dinov; Petros Petrosyan; Zhizhong Liu; Paul Eggert; Alen Zamanyan; Federica Torri; Fabio Macciardi; Sam Hobel; Seok Woo Moon; Young Hee Sung; Zhiguo Jiang; Jennifer Labus; Florian Kurth; Cody Ashe-McNalley; Emeran Mayer; Paul M Vespa; John D Van Horn; Arthur W Toga
Journal:  Brain Imaging Behav       Date:  2014-06       Impact factor: 3.978

Review 5.  Bioinformatics clouds for big data manipulation.

Authors:  Lin Dai; Xin Gao; Yan Guo; Jingfa Xiao; Zhang Zhang
Journal:  Biol Direct       Date:  2012-11-28       Impact factor: 4.540

6.  Genomic cloud computing: legal and ethical points to consider.

Authors:  Edward S Dove; Yann Joly; Anne-Marie Tassé; Bartha M Knoppers
Journal:  Eur J Hum Genet       Date:  2014-09-24       Impact factor: 4.246

Review 7.  Enabling large-scale biomedical analysis in the cloud.

Authors:  Ying-Chih Lin; Chin-Sheng Yu; Yen-Jen Lin
Journal:  Biomed Res Int       Date:  2013-10-31       Impact factor: 3.411

8.  Cloud based metalearning system for predictive modeling of biomedical data.

Authors:  Milan Vukićević; Sandro Radovanović; Miloš Milovanović; Miroslav Minović
Journal:  ScientificWorldJournal       Date:  2014-04-14

9.  VCGDB: a dynamic genome database of the Chinese population.

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10.  Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets.

Authors:  Allison P Heath; Matthew Greenway; Raymond Powell; Jonathan Spring; Rafael Suarez; David Hanley; Chai Bandlamudi; Megan E McNerney; Kevin P White; Robert L Grossman
Journal:  J Am Med Inform Assoc       Date:  2014-01-24       Impact factor: 4.497

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