Literature DB >> 22138182

Tristetraprolin down-regulates IL-17 through mRNA destabilization.

Hyun Hee Lee1, Nal Ae Yoon, Mai-Tram Vo, Chae Won Kim, Je Moon Woo, Hee Jeong Cha, Young Woo Cho, Byung Ju Lee, Wha Ja Cho, Jeong Woo Park.   

Abstract

An excess of interleukin 17 (IL-17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL-17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL-17 production in human T cell lines. Overexpression of TTP decreased the expression of IL-17. Conversely, TTP inhibition by siRNA increased IL-17 production. IL-17 mRNA contains eight AREs within its 3'UTR. TTP bound directly to the IL-17 mRNA 3'UTR at a location between the fourth and seventh AREs and enhanced decay of IL-17 transcripts. These results suggest that TTP could control IL-17-mediated inflammation.
Copyright © 2011. Published by Elsevier B.V.

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Year:  2011        PMID： 22138182     DOI： 10.1016/j.febslet.2011.11.021

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

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Review 7.  Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.

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8.  Tristetraprolin down-regulates IL-23 expression in colon cancer cells.

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Review 10.  TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications.

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Journal:  RNA Biol       Date:  2021-04-27       Impact factor: 4.652
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