| Literature DB >> 33866923 |
Yiwei Zhang1, Jian Zhou1, Zhiyuan Wei2, Hui Dong1, Di Yang1, Yuanyu Deng3, Jiahui Li3, Saiyu Shi3, Yi Sun4, Huimin Lu4, Jizhao Yuan1, Bing Ni5, Yuzhang Wu1,2, Yi Tian1,3, Chao Han1.
Abstract
Dendritic cells (DCs) form a sentinel network to induce protective immunity against pathogens or self-tolerance. mRNA stability is an important part of the post-transcriptional regulation (PTR) that controls the maturation and function of DCs. In this review, we summarize the effects of TTP-mediated regulation of mRNA stability in DCs, focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation. We also discuss the potential DC-based immune treatment for HIV+ patients through regulation of mRNA stability. This review proposes the regulation of mRNA stability as a novel immune therapy for various inflammatory diseases, such as arthritis and dermatitis.Entities:
Keywords: Dendritic cells; TTP; Zfp36; adaptive immunity; clinical application; immune tolerance; mRNA stability
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Year: 2021 PMID： 33866923 PMCID： PMC8632132 DOI： 10.1080/15476286.2021.1917185
Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652