OBJECTIVE: In this paper, we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients. METHODS: Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist (IL-1ra) were examined using the Luminex 100 system. RESULTS: Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAP patients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P<0.05), especially in SAP patients (n=25 of 36, P<0.05). The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P<0.05). CONCLUSIONS: CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.
OBJECTIVE: In this paper, we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients. METHODS: Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist (IL-1ra) were examined using the Luminex 100 system. RESULTS: Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAPpatients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P<0.05), especially in SAPpatients (n=25 of 36, P<0.05). The hospitalization time of SAPpatients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P<0.05). CONCLUSIONS: CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.
Authors: Adam Steensberg; Christian P Fischer; Charlotte Keller; Kirsten Møller; Bente Klarlund Pedersen Journal: Am J Physiol Endocrinol Metab Date: 2003-08 Impact factor: 4.310
Authors: Raymond E Biagini; Deborah L Sammons; Jerome P Smith; Barbara A MacKenzie; Cynthia A F Striley; Vera Semenova; Evelen Steward-Clark; Karen Stamey; Alison E Freeman; Conrad P Quinn; John E Snawder Journal: Clin Diagn Lab Immunol Date: 2004-01
Authors: Ziqi Lin; Chenlong Zhang; Xiaoxin Zhang; Na Shi; Yongjian Wen; Chengxia Han; Dan Du; Tingting Liu; Tao Jin; Lihui Deng; Kun Jiang; Xiaonan Yang; Jia Guo; Anthony Philips; Robert Sutton; John A Windsor; Wei Huang; Ping Xue; Qing Xia Journal: Evid Based Complement Alternat Med Date: 2020-02-10 Impact factor: 2.629