Literature DB >> 22128195

Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department.

Chadwick D Miller1, James W Hoekstra, Cedric Lefebvre, Howard Blumstein, Craig A Hamilton, Erin N Harper, Simon Mahler, Deborah B Diercks, Rebecca Neiberg, W Gregory Hundley.   

Abstract

BACKGROUND: Among intermediate- to high-risk patients with chest pain, we have shown that a cardiac magnetic resonance (CMR) stress test strategy implemented in an observation unit (OU) reduces 1-year health care costs compared with inpatient care. In this study, we compare 2 OU strategies to determine among lower-risk patients if a mandatory CMR stress test strategy was more effective than a physicians' ability to select a stress test modality. METHODS AND
RESULTS: On emergency department arrival and referral to the OU for management of low- to intermediate-risk chest pain, 120 individuals were randomly assigned to receive (1) a CMR stress imaging test (n=60) or (2) a provider-selected stress test (n=60: stress echo [62%], CMR [32%], cardiac catheterization [3%], nuclear [2%], and coronary CT [2%]). No differences were detected in length of stay (median CMR=24.2 hours versus 23.8 hours, P=0.75), catheterization without revascularization (CMR=0% versus 3%), appropriateness of admission decisions (CMR 87% versus 93%, P=0.36), or 30-day acute coronary syndrome (both 3%). Median cost was higher among those randomly assigned to the CMR-mandated group ($2005 versus $1686, P<0.001).
CONCLUSIONS: In patients with lower-risk chest pain receiving emergency department-directed OU care, the ability of a physician to select a cardiac stress imaging modality (including echocardiography, CMR, or radionuclide testing) was more cost-effective than a pathway that mandates a CMR stress test. Contrary to prior observations in individuals with intermediate- to high-risk chest pain, in those with lower-risk chest pain, these results highlight the importance of physician-related choices during acute coronary syndrome diagnostic protocols. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00869245.

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Year:  2011        PMID: 22128195      PMCID: PMC3272279          DOI: 10.1161/CIRCIMAGING.111.965293

Source DB:  PubMed          Journal:  Circ Cardiovasc Imaging        ISSN: 1941-9651            Impact factor:   7.792


  14 in total

1.  The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making.

Authors:  E M Antman; M Cohen; P J Bernink; C H McCabe; T Horacek; G Papuchis; B Mautner; R Corbalan; D Radley; E Braunwald
Journal:  JAMA       Date:  2000-08-16       Impact factor: 56.272

2.  Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia: a randomized controlled trial.

Authors:  James E Udelson; Joni R Beshansky; Daniel S Ballin; James A Feldman; John L Griffith; Jonathan Handler; Gary V Heller; Robert C Hendel; J Hector Pope; Robin Ruthazer; Ethan J Spiegler; Robert H Woolard; Harry P Selker
Journal:  JAMA       Date:  2002-12-04       Impact factor: 56.272

Review 3.  ACCF/AHA clinical competence statement on cardiac imaging with computed tomography and magnetic resonance: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training.

Authors:  Matthew J Budoff; Mylan C Cohen; Mario J Garcia; John McB Hodgson; W Gregory Hundley; Joao A C Lima; Warren J Manning; Gerald M Pohost; Paolo M Raggi; George P Rodgers; John A Rumberger; Allen J Taylor; Mark A Creager; John W Hirshfeld; Beverly H Lorell; Geno Merli; George P Rodgers; Cynthia M Tracy; Howard H Weitz
Journal:  J Am Coll Cardiol       Date:  2005-07-19       Impact factor: 24.094

4.  Impact on the care of the emergency department chest pain patient from the chest pain evaluation registry (CHEPER) study.

Authors:  L G Graff; J Dallara; M A Ross; A J Joseph; J Itzcovitz; R P Andelman; C Emerman; S Turbiner; J A Espinosa; H Severance
Journal:  Am J Cardiol       Date:  1997-09-01       Impact factor: 2.778

5.  Costs of an emergency department-based accelerated diagnostic protocol vs hospitalization in patients with chest pain: a randomized controlled trial.

Authors:  R R Roberts; R J Zalenski; E K Mensah; R J Rydman; G Ciavarella; L Gussow; K Das; L M Kampe; B Dickover; M F McDermott; A Hart; H E Straus; D G Murphy; R Rao
Journal:  JAMA       Date:  1997-11-26       Impact factor: 56.272

6.  Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography.

Authors:  W G Hundley; C A Hamilton; M S Thomas; D M Herrington; T B Salido; D W Kitzman; W C Little; K M Link
Journal:  Circulation       Date:  1999-10-19       Impact factor: 29.690

7.  An emergency department-based protocol for rapidly ruling out myocardial ischemia reduces hospital time and expense: results of a randomized study (ROMIO).

Authors:  M A Gomez; J L Anderson; L A Karagounis; J B Muhlestein; F B Mooers
Journal:  J Am Coll Cardiol       Date:  1996-07       Impact factor: 24.094

8.  Implications of 25% to 50% coronary stenosis with cardiac computed tomographic angiography in ED patients.

Authors:  Chadwick D Miller; Harold I Litt; Kim Askew; Daniel Entrikin; J Jeffrey Carr; Anna Marie Chang; Jane Kilkenny; Benjamin Weisenthal; Judd E Hollander
Journal:  Am J Emerg Med       Date:  2011-04-27       Impact factor: 2.469

9.  Prognosis of negative adenosine stress magnetic resonance in patients presenting to an emergency department with chest pain.

Authors:  W Patricia Ingkanisorn; Raymond Y Kwong; Nicole S Bohme; Nancy L Geller; Kenneth L Rhoads; Christopher K Dyke; D Ian Paterson; Mushabbar A Syed; Anthony H Aletras; Andrew E Arai
Journal:  J Am Coll Cardiol       Date:  2006-03-20       Impact factor: 24.094

10.  Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging.

Authors:  Raymond Y Kwong; Adam E Schussheim; Suresh Rekhraj; Anthony H Aletras; Nancy Geller; Janice Davis; Timothy F Christian; Robert S Balaban; Andrew E Arai
Journal:  Circulation       Date:  2003-02-04       Impact factor: 29.690

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  9 in total

Review 1.  Imaging techniques for the assessment of suspected acute coronary syndromes in the emergency department.

Authors:  Devang M Dave; Maros Ferencic; Udo Hoffmann; James E Udelson
Journal:  Curr Probl Cardiol       Date:  2014-05-05       Impact factor: 5.200

Review 2.  Emergency department observation units and the older patient.

Authors:  Mark G Moseley; Miles P Hawley; Jeffrey M Caterino
Journal:  Clin Geriatr Med       Date:  2013-02       Impact factor: 3.076

Review 3.  Non-ST-segment elevation acute coronary syndromes: targeted imaging to refine upstream risk stratification.

Authors:  Henry Chang; James K Min; Sunil V Rao; Manesh R Patel; Orlando P Simonetti; Giuseppe Ambrosio; Subha V Raman
Journal:  Circ Cardiovasc Imaging       Date:  2012-07       Impact factor: 7.792

4.  Cost analysis of the History, ECG, Age, Risk factors, and initial Troponin (HEART) Pathway randomized control trial.

Authors:  Robert F Riley; Chadwick D Miller; Gregory B Russell; Erin N Harper; Brian C Hiestand; James W Hoekstra; Cedric W Lefebvre; Bret A Nicks; David M Cline; Kim L Askew; Simon A Mahler
Journal:  Am J Emerg Med       Date:  2016-10-05       Impact factor: 2.469

5.  Monocyte Chemoattractant Protein-1 as a Predictor of Coronary Atherosclerosis in Patients Receiving Coronary Angiography.

Authors:  Simon A Mahler; Thomas C Register; Robert F Riley; Ralph B D'Agostino; Jason P Stopyra; Chadwick D Miller
Journal:  Crit Pathw Cardiol       Date:  2018-06

6.  Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain.

Authors:  Chadwick D Miller; L Douglas Case; William C Little; Simon A Mahler; Gregory L Burke; Erin N Harper; Cedric Lefebvre; Brian Hiestand; James W Hoekstra; Craig A Hamilton; W Gregory Hundley
Journal:  JACC Cardiovasc Imaging       Date:  2013-05-08

7.  Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation.

Authors:  Simon A Mahler; Brian C Hiestand; Jamaji Nwanaji-Enwerem; David C Goff; Gregory L Burke; L Douglas Case; Bret Nicks; Chadwick D Miller
Journal:  Acad Emerg Med       Date:  2013-03       Impact factor: 3.451

8.  Myocardial deformation by strain echocardiography identifies patients with acute coronary syndrome and non-diagnostic ECG presenting in a chest pain unit: a prospective study of diagnostic accuracy.

Authors:  Joerg Schroeder; Sandra Hamada; Nina Gründlinger; Tanja Rubeau; Ertunc Altiok; Katrin Ulbrich; Andras Keszei; Nikolaus Marx; Michael Becker
Journal:  Clin Res Cardiol       Date:  2015-09-08       Impact factor: 5.460

Review 9.  Hospitalisation in short-stay units for adults with internal medicine diseases and conditions.

Authors:  Camilla Strøm; Jakob S Stefansson; Maria Louise Fabritius; Lars S Rasmussen; Thomas A Schmidt; Janus C Jakobsen
Journal:  Cochrane Database Syst Rev       Date:  2018-08-13
  9 in total

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