Literature DB >> 22122509

A-kinase anchoring proteins as potential drug targets.

Jessica Tröger1, Marie C Moutty, Philipp Skroblin, Enno Klussmann.   

Abstract

A-kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales. In particular, AKAPs mediate compartmentalization of cAMP signalling. Alterations in AKAP expression and their interactions are associated with or cause diseases including chronic heart failure, various cancers and disorders of the immune system such as HIV. A number of cellular dysfunctions result from mutations of specific AKAPs. The link between malfunctions of single AKAP complexes and a disease makes AKAPs and their interactions interesting targets for the development of novel drugs. LINKED ARTICLES This article is part of a themed section on Novel cAMP Signalling Paradigms. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.166.issue-2.
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

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Year:  2012        PMID： 22122509      PMCID： PMC3417477          DOI： 10.1111/j.1476-5381.2011.01796.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  155 in total

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Review 5.  AKAPs: the architectural underpinnings of local cAMP signaling.

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Review 4.  Local cAMP signaling in disease at a glance.

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5.  A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton.

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7.  A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.

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9.  Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM.

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