Literature DB >> 22122073

Assembly of the presenilin γ-/ε-secretase complex.

P St George-Hyslop1,2, P E Fraser1,3.   

Abstract

The presenilin complex is composed of four core proteins (presenilin 1 or presenilin 2, APH1, nicastrin, and PEN2). Several endogenous proteins have been reported to selectively modulate the function of the presenilin complexes; these include transmembrane trafficking protein, 21-KD (TMP21), CD147 antigen (basigin), the γ-secretase-activating protein (gSAP), and the orphan G-protein-coupled receptor 3. Because the structure and assembly of these complexes underlies their activity, this review will discuss current work on the assembly of the complex and on presenilin-interacting proteins that regulate secretase activity.
© 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.

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Year:  2011        PMID： 22122073     DOI： 10.1111/j.1471-4159.2011.07505.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.546


  16 in total

1.  Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.

Authors:  Hasane Ratni; Andre Alker; Bjoern Bartels; Caterina Bissantz; Weichun Chen; Irene Gerlach; Anja Limberg; Mingqiu Lu; Werner Neidhart; Solen Pichereau; Michael Reutlinger; Rosa-Maria Rodriguez-Sarmiento; Roland Jakob-Roetne; Georg Schmitt; Eric Zhang; Karlheinz Baumann
Journal:  ACS Med Chem Lett       Date:  2020-04-27       Impact factor: 4.345

2.  Leptin regulates amyloid β production via the γ-secretase complex.

Authors:  Dana M Niedowicz; Christa M Studzinski; Adam M Weidner; Thomas L Platt; Kristen N Kingry; Tina L Beckett; Annadora J Bruce-Keller; Jeffrey N Keller; M Paul Murphy
Journal:  Biochim Biophys Acta       Date:  2012-12-26

Review 3.  More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.

Authors:  Courtney Lane-Donovan; Gary T Philips; Joachim Herz
Journal:  Neuron       Date:  2014-08-20       Impact factor: 17.173

4.  Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice.

Authors:  Wenjun Fu; Yuan Dai; Tao Ma; Jiangping Wei; Huan Chen; Shijun Xu
Journal:  Exp Ther Med       Date:  2018-02-26       Impact factor: 2.447

5.  Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.

Authors:  Sylvia E Perez; Muhammad Nadeem; Michael H Malek-Ahmadi; Bin He; Elliott J Mufson
Journal:  Neurodegener Dis       Date:  2017-07-26       Impact factor: 2.977

6.  Betaine suppressed Aβ generation by altering amyloid precursor protein processing.

Authors:  Xiu-Ping Liu; Xiang Qian; Yue Xie; Yan Qi; Min-Feng Peng; Bi-Cui Zhan; Zheng-Qing Lou
Journal:  Neurol Sci       Date:  2014-02-19       Impact factor: 3.307

7.  Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.

Authors:  Angels Almenar-Queralt; Sonia N Kim; Christopher Benner; Cheryl M Herrera; David E Kang; Ivan Garcia-Bassets; Lawrence S B Goldstein
Journal:  J Biol Chem       Date:  2013-10-21       Impact factor: 5.157

8.  Twenty Years of Presenilins--Important Proteins in Health and Disease.

Authors:  Jochen Walter
Journal:  Mol Med       Date:  2015-10-27       Impact factor: 6.354

9.  Canonical correlation analysis for RNA-seq co-expression networks.

Authors:  Shengjun Hong; Xiangning Chen; Li Jin; Momiao Xiong
Journal:  Nucleic Acids Res       Date:  2013-03-04       Impact factor: 16.971

Review 10.  The very many faces of presenilins and the γ-secretase complex.

Authors:  Michalina Smolarkiewicz; Tomasz Skrzypczak; Przemysław Wojtaszek
Journal:  Protoplasma       Date:  2013-03-16       Impact factor: 3.356
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