Literature DB >> 25144875

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.

Courtney Lane-Donovan1, Gary T Philips2, Joachim Herz3.   

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25144875      PMCID： PMC4240629          DOI： 10.1016/j.neuron.2014.08.005

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  244 in total

1.  Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor.

Authors:  Hyang-Sook Hoe; Ana Pocivavsek; Geetanjali Chakraborty; Zhanyan Fu; Stefano Vicini; Michael D Ehlers; G William Rebeck
Journal:  J Biol Chem       Date:  2005-12-06       Impact factor: 5.157

2.  Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease.

Authors:  Arancha Botella-López; Inmaculada Cuchillo-Ibáñez; Tiziana Cotrufo; Su San Mok; Qiao-Xin Li; María-Sagrario Barquero; Mara Dierssen; Eduardo Soriano; Javier Sáez-Valero
Journal:  Neurobiol Dis       Date:  2009-12-16       Impact factor: 5.996

3.  Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

Authors:  A M Cataldo; J L Barnett; C Pieroni; R A Nixon
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

4.  Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.

Authors:  Uwe Beffert; Gerardo Morfini; Hans H Bock; Huichuan Reyna; Scott T Brady; Joachim Herz
Journal:  J Biol Chem       Date:  2002-10-09       Impact factor: 5.157

5.  The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.

Authors:  U Beffert; C Arguin; J Poirier
Journal:  Neurosci Lett       Date:  1999-01-04       Impact factor: 3.046

Review 6.  Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Authors:  Robert W Mahley; Yadong Huang
Journal:  Neuron       Date:  2012-12-06       Impact factor: 17.173

Review 7.  Pathogenesis of cerebral amyloid angiopathy.

Authors:  Annemieke A M Rensink; Robert M W de Waal; Berry Kremer; Marcel M Verbeek
Journal:  Brain Res Brain Res Rev       Date:  2003-10

8.  The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

Authors:  M Z Kounnas; W S Argraves; D K Strickland
Journal:  J Biol Chem       Date:  1992-10-15       Impact factor: 5.157

Review 9.  Role of reelin in the control of brain development.

Authors:  T Curran; G D'Arcangelo
Journal:  Brain Res Brain Res Rev       Date:  1998-05

10.  The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

Authors:  Judy A Cam; Celina V Zerbinatti; Jane M Knisely; Silva Hecimovic; Yonghe Li; Guojun Bu
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157
View more
  66 in total

1.  To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease.

Authors:  Maria G Grammatikopoulou; Dimitrios G Goulis; Konstantinos Gkiouras; Xenophon Theodoridis; Kalliopi K Gkouskou; Athanasios Evangeliou; Efthimis Dardiotis; Dimitrios P Bogdanos
Journal:  Adv Nutr       Date:  2020-11-16       Impact factor: 8.701

2.  ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.

Authors:  Jane E Salmon; Chieko Mineo; Victoria Ulrich; Shari E Gelber; Milena Vukelic; Anastasia Sacharidou; Joachim Herz; Rolf T Urbanus; Philip G de Groot; David R Natale; Anirudha Harihara; Patricia Redecha; Vikki M Abrahams; Philip W Shaul
Journal:  Arthritis Rheumatol       Date:  2016-03       Impact factor: 10.995

Review 3.  Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights.

Authors:  Venkat Raghavan Krishnaswamy; Amit Benbenishty; Pablo Blinder; Irit Sagi
Journal:  Cell Mol Life Sci       Date:  2019-06-13       Impact factor: 9.261

Review 4.  Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.

Authors:  Ralph A Nixon
Journal:  FASEB J       Date:  2017-07       Impact factor: 5.191

5.  Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Authors:  Grace Woodruff; Sol M Reyna; Mariah Dunlap; Rik Van Der Kant; Julia A Callender; Jessica E Young; Elizabeth A Roberts; Lawrence S B Goldstein
Journal:  Cell Rep       Date:  2016-10-11       Impact factor: 9.423

6.  Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization.

Authors:  Charina S Fabilane; Patricia N Nguyen; Roy V Hernandez; Sasidhar Nirudodhi; Mai Duong; Claudia S Maier; Vasanthy Narayanaswami
Journal:  Protein Pept Lett       Date:  2016       Impact factor: 1.890

7.  Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.

Authors:  Tina Bilousova; Mikhail Melnik; Emily Miyoshi; Bianca L Gonzalez; Wayne W Poon; Harry V Vinters; Carol A Miller; Maria M Corrada; Claudia Kawas; Asa Hatami; Ricardo Albay; Charles Glabe; Karen H Gylys
Journal:  Am J Pathol       Date:  2019-05-17       Impact factor: 4.307

8.  Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.

Authors:  Xuesong Chen; Liang Hui; Mahmoud L Soliman; Jonathan D Geiger
Journal:  J Parkinsons Dis Alzheimers Dis       Date:  2014

Review 9.  Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence.

Authors:  Yu Yamazaki; Meghan M Painter; Guojun Bu; Takahisa Kanekiyo
Journal:  CNS Drugs       Date:  2016-09       Impact factor: 5.749

10.  Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.

Authors:  Na Zhao; Chia-Chen Liu; Alexandra J Van Ingelgom; Yuka A Martens; Cynthia Linares; Joshua A Knight; Meghan M Painter; Patrick M Sullivan; Guojun Bu
Journal:  Neuron       Date:  2017-09-27       Impact factor: 17.173
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.