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Literature DB >> 22121499

Direct amide formation from unactivated carboxylic acids and amines.

C Liana Allen¹, A Rosie Chhatwal, Jonathan M J Williams.

Abstract

The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.

Entities: Chemical

Year: 2011 PMID： 22121499 DOI： 10.1039/c1cc15210f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

17 in total

1. Elucidating the Role of Antisolvents on the Surface Chemistry and Optoelectronic Properties of CsPbBr_xI_3-x Perovskite Nanocrystals.

Authors: Junzhi Ye; Zhenchao Li; Dominik J Kubicki; Yunwei Zhang; Linjie Dai; Clara Otero-Martínez; Manuel A Reus; Rakesh Arul; Kavya Reddy Dudipala; Zahra Andaji-Garmaroudi; Yi-Teng Huang; Zewei Li; Ziming Chen; Peter Müller-Buschbaum; Hin-Lap Yip; Samuel D Stranks; Clare P Grey; Jeremy J Baumberg; Neil C Greenham; Lakshminarayana Polavarapu; Akshay Rao; Robert L Z Hoye
Journal: J Am Chem Soc Date: 2022-06-27 Impact factor: 16.383

2. Borate esters: Simple catalysts for the sustainable synthesis of complex amides.

Authors: Marco T Sabatini; Lee T Boulton; Tom D Sheppard
Journal: Sci Adv Date: 2017-09-22 Impact factor: 14.136

3. Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl₄.

Authors: Antonella Leggio; Jessica Bagalà; Emilia Lucia Belsito; Alessandra Comandè; Marianna Greco; Angelo Liguori
Journal: Chem Cent J Date: 2017-09-15 Impact factor: 4.215

4. Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl₂.

Authors: Lidan Cheng; Xiaoping Ge; Longjiang Huang
Journal: R Soc Open Sci Date: 2018-02-21 Impact factor: 2.963

5. Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts.

Authors: Marco T Sabatini; Valerija Karaluka; Rachel M Lanigan; Lee T Boulton; Matthew Badland; Tom D Sheppard
Journal: Chemistry Date: 2018-04-30 Impact factor: 5.236

6. (E)-Ethyl-2-cyano-2-(((2,4,6-trichlorobenzoyl)oxy)imino)acetate: A Modified Yamaguchi Reagent for Enantioselective Esterification, Thioesterification, Amidation, and Peptide Synthesis.

Authors: Jyoti Chandra; Srinivasa Rao Manne; Sandip Mondal; Bhubaneswar Mandal
Journal: ACS Omega Date: 2018-06-06

Direct amide formation from unactivated carboxylic acids and amines.

1. Elucidating the Role of Antisolvents on the Surface Chemistry and Optoelectronic Properties of CsPbBr_xI_3-x Perovskite Nanocrystals.

2. Borate esters: Simple catalysts for the sustainable synthesis of complex amides.

3. Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl₄.

4. Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl₂.

5. Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts.

6. (E)-Ethyl-2-cyano-2-(((2,4,6-trichlorobenzoyl)oxy)imino)acetate: A Modified Yamaguchi Reagent for Enantioselective Esterification, Thioesterification, Amidation, and Peptide Synthesis.

7. Direct synthesis of amides from carboxylic acids and amines using B(OCH2CF3)3.

8. Atom-economic catalytic amide synthesis from amines and carboxylic acids activated in situ with acetylenes.

9. Molecular-oxygen-promoted Cu-catalyzed oxidative direct amidation of nonactivated carboxylic acids with azoles.

10. Microwave-Assisted Catalytic Method for a Green Synthesis of Amides Directly from Amines and Carboxylic Acids.