Literature DB >> 2211984

Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis.

C A Kappel1, R W Melvold, B S Kim.   

Abstract

Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2211984     DOI： 10.1016/0165-5728(90)90143-b

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  14 in total

1.  Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.

Authors:  F Bihl; M Brahic; J F Bureau
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

Review 2.  Strain-Related Differences in the Immune Response: Relevance to Human Stroke.

Authors:  Kyra J Becker
Journal:  Transl Stroke Res       Date:  2016-02-10       Impact factor: 6.829

Review 3.  Understanding sex biases in immunity: effects of estrogen on the differentiation and function of antigen-presenting cells.

Authors:  Greg Nalbandian; Susan Kovats
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

4.  Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis.

Authors:  Ikuo Tsunoda; Fumitaka Sato; Seiichi Omura; Mitsugu Fujita; Namie Sakiyama; Ah-Mee Park
Journal:  Clin Exp Neuroimmunol       Date:  2016-10-25

5.  Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.

Authors:  Russell J Butterfield; Randall J Roper; Dominic M Rhein; Roger W Melvold; Lia Haynes; Runlin Z Ma; R W Doerge; Cory Teuscher
Journal:  Genetics       Date:  2003-03       Impact factor: 4.562

6.  Association between susceptibility to Theiler's virus-induced demyelination and T-cell receptor Jbeta1-Cbeta1 polymorphism rather than Vbeta deletion.

Authors:  Y Y Bahk; C A Kappel; G Rasmussen; B S Kim
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

7.  Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.

Authors:  Erin E Young; Amy N Sieve; Elisabeth G Vichaya; Luis M Carcoba; Colin R Young; Andrew Ambrus; Ralph Storts; C Jane R Welsh; Mary W Meagher
Journal:  J Neuroimmunol       Date:  2010-02-18       Impact factor: 3.478

8.  Effects of ovarian steroids on immunoglobulin-secreting cell function in healthy women.

Authors:  Fabien X Lü; Zhongmin Ma; Susie Moser; Thomas G Evans; Christopher J Miller
Journal:  Clin Diagn Lab Immunol       Date:  2003-09

9.  Analysis of antibody responses to predominant linear epitopes of Theiler's murine encephalomyelitis virus.

Authors:  A Inoue; Y K Choe; B S Kim
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

Review 10.  Gender and sex hormones in multiple sclerosis pathology and therapy.

Authors:  Arnaud Nicot
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.