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Literature DB >> 12663542

Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.

Russell J Butterfield¹, Randall J Roper, Dominic M Rhein, Roger W Melvold, Lia Haynes, Runlin Z Ma, R W Doerge, Cory Teuscher.

Abstract

Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a mouse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL) controlling TMEVD severity in male and female backcross populations derived from susceptible DBA/2J and resistant BALBc/ByJ mice. We report QTL on chromosomes 1, 5, 15, and 16 affecting male mice. In addition, we identified two QTL in female mice located on chromosome 1. Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice.

Entities: Disease Gene Species

Mesh：

Year: 2003 PMID： 12663542 PMCID： PMC1462488

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

41 in total

1. Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.

Authors: F Bihl; M Brahic; J F Bureau
Journal: Genetics Date: 1999-05 Impact factor: 4.562

2. Mutation of a major histocompatibility class I locus, H-2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease.

Authors: H L Lipton; R Melvold; S D Miller; M C Dal Canto
Journal: J Neurovirol Date: 1995-06 Impact factor: 2.643

3. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice.

Authors: R J Butterfield; J D Sudweeks; E P Blankenhorn; R Korngold; J C Marini; J A Todd; R J Roper; C Teuscher
Journal: J Immunol Date: 1998-08-15 Impact factor: 5.422

Review 4. Genetics of susceptibility to Theiler's virus infection.

Authors: M Brahic; J F Bureau
Journal: Bioessays Date: 1998-08 Impact factor: 4.345

Review 5. Viruses and multiple sclerosis.

Authors: A G Dalgleish
Journal: Acta Neurol Scand Suppl Date: 1997

6. Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.

Authors: J F Bureau; K M Drescher; L R Pease; T Vikoren; M Delcroix; L Zoecklein; M Brahic; M Rodriguez
Journal: Genetics Date: 1998-04 Impact factor: 4.562

7. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct.

Authors: R J Butterfield; E P Blankenhorn; R J Roper; J F Zachary; R W Doerge; J Sudweeks; J Rose; C Teuscher
Journal: J Immunol Date: 1999-03-01 Impact factor: 5.422

8. Gender variations in early Theiler's virus induced demyelinating disease: differential susceptibility and effects of IL-4, IL-10 and combined IL-4 with IL-10.

Authors: K E Hill; M Pigmans; R S Fujinami; J W Rose
Journal: J Neuroimmunol Date: 1998-05-01 Impact factor: 3.478

9. Evidence that Tmevd2 and eae3 may represent either a common locus or members of a gene complex controlling susceptibility to immunologically mediated demyelination in mice.

Authors: C Teuscher; D M Rhein; K D Livingstone; R A Paynter; R W Doerge; S M Nicholson; R W Melvold
Journal: J Immunol Date: 1997-11-15 Impact factor: 5.422

10. Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.

Authors: N D Meeker; W F Hickey; R Korngold; W K Hansen; J D Sudweeks; B B Wardell; J S Griffith; C Teuscher
Journal: Proc Natl Acad Sci U S A Date: 1995-06-06 Impact factor: 11.205

16 in total

1. Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.

Authors: Elena Kudryavtseva; Toni S Forde; Andrew D Pucker; Vyacheslav A Adarichev
Journal: Arthritis Rheum Date: 2011-10-17

2. Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice.

Authors: K M Spach; L K Case; R Noubade; C B Petersen; B McElvany; N Zalik; W F Hickey; E P Blankenhorn; C Teuscher
Journal: Genes Immun Date: 2010-09-23 Impact factor: 2.676

3. Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection.

Authors: Iryna Kurey; Tetyana Kobets; Helena Havelková; Martina Slapnicková; Lei Quan; Katerina Trtková; Igor Grekov; Milena Svobodová; Alphons P Stassen; Alan Hutson; Peter Demant; Marie Lipoldová
Journal: Immunogenetics Date: 2009-08-25 Impact factor: 2.846

4. Genetic control of resistance to Trypanosoma brucei brucei infection in mice.

Authors: Matyáš Síma; Helena Havelková; Lei Quan; Milena Svobodová; Taťána Jarošíková; Jarmila Vojtíšková; Alphons P M Stassen; Peter Demant; Marie Lipoldová
Journal: PLoS Negl Trop Dis Date: 2011-06-07

5. Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice.

Authors: Daniel R Prows; William J Gibbons; Benjamin B Burzynski
Journal: PLoS One Date: 2012-05-29 Impact factor: 3.240

10. A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.

Authors: Chenguang Wang; Yun Cheng; Tian Liu; Qin Li; Roger B Fillingim; Margaret R Wallace; Roland Staud; Lee Kaplan; Rongling Wu
Journal: Mol Pain Date: 2008-04-16 Impact factor: 3.395