| Literature DB >> 22119469 |
Noel A Powell1, Jeffrey T Kohrt, Kevin J Filipski, Michael Kaufman, Derek Sheehan, Jeremy E Edmunds, Amy Delaney, Yuli Wang, Francis Bourbonais, Doh-Yeel Lee, Frank Schwende, Fang Sun, Pat McConnell, Cornel Catana, Huifen Chen, Jeff Ohren, Lisa A Perrin.
Abstract
We report the discovery of a novel series of spiroindoline-based inhibitors of Sky kinase that bind in the ATP-binding site and exhibit high levels of kinome selectivity through filling the Ala571-subpocket. These inhibitors exhibit moderate oral bioavailability in the rat due to low absorption across the gut wall.Entities:
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Year: 2011 PMID： 22119469 DOI： 10.1016/j.bmcl.2011.11.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823