Literature DB >> 30714403

TYRO3: A potential therapeutic target in cancer.

Pei-Ling Hsu1, Jonathan Jou2, Shaw-Jenq Tsai1.   

Abstract

IMPACT STATEMENT: Cancer is among the leading causes of death worldwide. In 2016, 8.9 million people are estimated to have died from various forms of cancer. The current treatments, including surgery with chemotherapy and/or radiation therapy, are not effective enough to provide full protection from cancer, which highlights the need for developing novel therapy strategies. In this review, we summarize the molecular biology of a unique member of a subfamily of receptor tyrosine kinase, TYRO3 and discuss the new insights in TYRO3-targeted treatment for cancer therapy.

Entities:  

Keywords:  Cancer; TAM; TYRO3; drug discovery; therapeutic potential

Mesh：

Substances：

Year:  2019        PMID： 30714403      PMCID： PMC6405828          DOI： 10.1177/1535370219828195

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  185 in total

1.  Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

Authors:  Q Lu; G Lemke
Journal:  Science       Date:  2001-07-13       Impact factor: 47.728

2.  Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.

Authors:  Q Lu; M Gore; Q Zhang; T Camenisch; S Boast; F Casagranda; C Lai; M K Skinner; R Klein; G K Matsushima; H S Earp; S P Goff; G Lemke
Journal:  Nature       Date:  1999-04-22       Impact factor: 49.962

3.  Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.

Authors:  Z Lan; H Wu; W Li; S Wu; L Lu; M Xu; W Dai
Journal:  Blood       Date:  2000-01-15       Impact factor: 22.113

4.  Synthesis and secretion of the anticoagulant protein S and coexpression of the Tyro3 receptor in human lung carcinoma cells.

Authors:  A Wimmel; I Rohner; A Ramaswamy; H H Heidtmann; R Seitz; M Kraus; M Schuermann
Journal:  Cancer       Date:  1999-07-01       Impact factor: 6.860

5.  Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina.

Authors:  S Ikeda; W He; A Ikeda; J K Naggert; M A North; P M Nishina
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-10       Impact factor: 4.799

6.  Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays.

Authors:  J De Vos; G Couderc; K Tarte; M Jourdan; G Requirand; M C Delteil; J F Rossi; N Mechti; B Klein
Journal:  Blood       Date:  2001-08-01       Impact factor: 22.113

7.  tie-1 protein tyrosine kinase: a novel independent prognostic marker for gastric cancer.

Authors:  W C Lin; A F Li; C W Chi; W W Chung; C L Huang; W Y Lui; H J Kung; C W Wu
Journal:  Clin Cancer Res       Date:  1999-07       Impact factor: 12.531

8.  Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines.

Authors:  W Dirks; D Rome; F Ringel; K Jäger; R A MacLeod; H G Drexler
Journal:  Leuk Res       Date:  1999-07       Impact factor: 3.156

9.  Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.

Authors:  M Katagiri; Y Hakeda; D Chikazu; T Ogasawara; T Takato; M Kumegawa; K Nakamura; H Kawaguchi
Journal:  J Biol Chem       Date:  2000-11-17       Impact factor: 5.157

10.  Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

Authors:  A Angelillo-Scherrer; P de Frutos; C Aparicio; E Melis; P Savi; F Lupu; J Arnout; M Dewerchin; M Hoylaerts; J Herbert; D Collen; B Dahlbäck; P Carmeliet
Journal:  Nat Med       Date:  2001-02       Impact factor: 53.440
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  2 in total

1.  TYRO3 facilitates cell growth and metastasis via activation of the Wnt/β-catenin signaling pathway in human gastric cancer cells.

Authors:  Dehu Chen; Qinghong Liu; Gan Cao; Wei Zhang
Journal:  Aging (Albany NY)       Date:  2020-02-04       Impact factor: 5.682

2.  Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis.

Authors:  Nour Al Kafri; Sassan Hafizi
Journal:  Cancers (Basel)       Date:  2019-11-22       Impact factor: 6.639
  2 in total

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