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Literature DB >> 22119143

Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity.

Abstract

Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.

Entities: Chemical Disease Gene Mutation Species

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Year: 2011 PMID： 22119143 PMCID： PMC3294416 DOI： 10.1016/j.conb.2011.10.008

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

66 in total

1. Reversible neural inactivation reveals hippocampal participation in several memory processes.

Authors: G Riedel; J Micheau; A G Lam; E L Roloff; S J Martin; H Bridge; L de Hoz; B Poeschel; J McCulloch; R G Morris
Journal: Nat Neurosci Date: 1999-10 Impact factor: 24.884

2. Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

Authors: David D McKemy; Werner M Neuhausser; David Julius
Journal: Nature Date: 2002-02-10 Impact factor: 49.962

3. Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map.

Authors: C Ron Yu; Jennifer Power; Gilad Barnea; Sean O'Donnell; Hannah E V Brown; Joseph Osborne; Richard Axel; Joseph A Gogos
Journal: Neuron Date: 2004-05-27 Impact factor: 17.173

4. Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.

Authors: Takatoshi Hikida; Kensuke Kimura; Norio Wada; Kazuo Funabiki; Shigetada Nakanishi
Journal: Neuron Date: 2010-06-24 Impact factor: 17.173

5. Selective erasure of a fear memory.

Authors: Jin-Hee Han; Steven A Kushner; Adelaide P Yiu; Hwa-Lin Liz Hsiang; Thorsten Buch; Ari Waisman; Bruno Bontempi; Rachael L Neve; Paul W Frankland; Sheena A Josselyn
Journal: Science Date: 2009-03-13 Impact factor: 47.728

6. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.

Authors: Russell S Ray; Andrea E Corcoran; Rachael D Brust; Jun Chul Kim; George B Richerson; Eugene Nattie; Susan M Dymecki
Journal: Science Date: 2011-07-29 Impact factor: 47.728

7. Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons.

Authors: Devon C Crawford; Krista L Moulder; Robert W Gereau; Gina M Story; Steven Mennerick
Journal: PLoS One Date: 2009-12-04 Impact factor: 3.240

8. Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons.

Authors: Boris V Zemelman; Nasri Nesnas; Georgia A Lee; Gero Miesenbock
Journal: Proc Natl Acad Sci U S A Date: 2003-01-22 Impact factor: 11.205

Review 9. New photochemical tools for controlling neuronal activity.

Authors: Richard H Kramer; Doris L Fortin; Dirk Trauner
Journal: Curr Opin Neurobiol Date: 2009-10-12 Impact factor: 6.627

10. Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.

Authors: K Kobayashi; S Morita; H Sawada; T Mizuguchi; K Yamada; I Nagatsu; K Fujita; R J Kreitman; I Pastan; T Nagatsu
Journal: Proc Natl Acad Sci U S A Date: 1995-02-14 Impact factor: 12.779

14 in total

Review 1. Molecular neuroanatomy: a generation of progress.

Authors: Jonathan D Pollock; Da-Yu Wu; John S Satterlee
Journal: Trends Neurosci Date: 2013-12-31 Impact factor: 13.837

Review 2. Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

Authors: David Weinshenker; Philip V Holmes
Journal: Brain Res Date: 2015-11-20 Impact factor: 3.252

3. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake.

Authors: Kavon Rezai-Zadeh; Sanghou Yu; Yanyan Jiang; Amanda Laque; Candice Schwartzenburg; Christopher D Morrison; Andrei V Derbenev; Andrea Zsombok; Heike Münzberg
Journal: Mol Metab Date: 2014-08-06 Impact factor: 7.422

Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity.

1. Reversible neural inactivation reveals hippocampal participation in several memory processes.

2. Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

3. Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map.

4. Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.

5. Selective erasure of a fear memory.

6. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.

7. Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons.

8. Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons.

Review 9. New photochemical tools for controlling neuronal activity.

10. Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.

Review 1. Molecular neuroanatomy: a generation of progress.

Review 2. Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

3. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake.

Review 4. Beyond the bolus: transgenic tools for investigating the neurophysiology of learning and memory.

Review 5. Dissecting inhibitory brain circuits with genetically-targeted technologies.

6. Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons.

7. Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches.

Review 8. Genetic dissection of GABAergic neural circuits in mouse neocortex.

9. Chemical-genetic attenuation of focal neocortical seizures.

10. The opto-locomotor reflex as a tool to measure sensitivity to moving random dot patterns in mice.