Literature DB >> 22116774

Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML.

Ana Rosa S Costa1, Sintia I Belangero, Maria Isabel Melaragno, Maria de Lourdes Chauffaille.   

Abstract

Improved outcome of acute myeloid leukemia (AML) depends on the better differentiation of subtypes to predict treatment response and the identification of new target for treatment. In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis.

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Year:  2011        PMID： 22116774     DOI： 10.1007/s12032-011-0108-5

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  12 in total

1.  Detection of large-scale variation in the human genome.

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Review 6.  Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia.

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Review 8.  The array CGH and its clinical applications.

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  4 in total

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3.  Identifying the similarities and differences between single nucleotide polymorphism array (SNPa) analysis and karyotyping in acute myeloid leukemia and myelodysplastic syndromes.

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4.  WT1 Gene Mutations, rs16754 Variant, and WT1 Overexpression as Prognostic Factors in Acute Myeloid Leukemia Patients.

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  4 in total

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