PURPOSE: To investigate the association between SEPTIN12 gene variants and the risk of azoospermia caused by meiotic arrest. METHODS: Mutational analysis of the SEPTIN12 gene was performed using DNA from 30 Japanese patients with azoospermia by meiotic arrest and 140 fertile male controls. RESULTS: The frequencies of the c.204G>C (Gln38His) allele and the CC genotype were significantly higher in patients than in fertile controls (p < 0.05). CONCLUSION: The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest.
PURPOSE: To investigate the association between SEPTIN12 gene variants and the risk of azoospermia caused by meiotic arrest. METHODS: Mutational analysis of the SEPTIN12 gene was performed using DNA from 30 Japanese patients with azoospermia by meiotic arrest and 140 fertile male controls. RESULTS: The frequencies of the c.204G>C (Gln38His) allele and the CC genotype were significantly higher in patients than in fertile controls (p < 0.05). CONCLUSION: The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest.
Authors: Michael A Crackower; Nadine K Kolas; Junko Noguchi; Renu Sarao; Kazuhiro Kikuchi; Hiroyuki Kaneko; Eiji Kobayashi; Yasuhiro Kawai; Ivona Kozieradzki; Rushin Landers; Rong Mo; Chi-Chung Hui; Edward Nieves; Paula E Cohen; Lucy R Osborne; Teiji Wada; Tetsuo Kunieda; Peter B Moens; Josef M Penninger Journal: Science Date: 2003-05-23 Impact factor: 47.728
Authors: A Tsujimura; K Matsumiya; Y Miyagawa; A Tohda; H Miura; K Nishimura; M Koga; M Takeyama; H Fujioka; A Okuyama Journal: Hum Reprod Date: 2002-11 Impact factor: 6.918