BACKGROUND: The effect of local infiltration after breast surgery is controversial. This prospective double blind randomized study sought to document the analgesic effect of local anaesthetic infiltration after breast cancer surgery. METHODS: Patients scheduled for mastectomy or tumorectomy and axillary nodes dissection had immediate postoperative infiltration of the surgical wound with 20 ml of ropivacaine 7.5 mg.ml-1 or isotonic saline. Pain was assessed on a visual analogue scale at H2, H4, H6, H12, H24, H72, and at 2 month, at rest and on mobilization of the arm. Patient'comfort was evaluated with numerical 0-3 scales for fatigue, quality of sleep, state of mood, social function and activity. RESULTS:Twenty-two and 24 patients were included in theropivacaine and saline groups respectively. Postoperative pain was lower at rest and on mobilization at 2, 4 and 6 hour after surgery in the ropivacaine group. No other difference in pain intensity and patient 'comfort scoring was documented during the first 3 postoperative days. Patients did not differ at 2 month for pain and comfort scores. CONCLUSION: Single shot infiltration with ropivacaine transiently improves postoperative pain controlafter breast cancer surgery. TRIAL REGISTRATION NUMBER: NCT01404377.
RCT Entities:
BACKGROUND: The effect of local infiltration after breast surgery is controversial. This prospective double blind randomized study sought to document the analgesic effect of local anaesthetic infiltration after breast cancer surgery. METHODS:Patients scheduled for mastectomy or tumorectomy and axillary nodes dissection had immediate postoperative infiltration of the surgical wound with 20 ml of ropivacaine 7.5 mg.ml-1 or isotonic saline. Pain was assessed on a visual analogue scale at H2, H4, H6, H12, H24, H72, and at 2 month, at rest and on mobilization of the arm. Patient'comfort was evaluated with numerical 0-3 scales for fatigue, quality of sleep, state of mood, social function and activity. RESULTS: Twenty-two and 24 patients were included in the ropivacaine and saline groups respectively. Postoperative pain was lower at rest and on mobilization at 2, 4 and 6 hour after surgery in the ropivacaine group. No other difference in pain intensity and patient 'comfort scoring was documented during the first 3 postoperative days. Patients did not differ at 2 month for pain and comfort scores. CONCLUSION: Single shot infiltration with ropivacaine transiently improves postoperative pain control after breast cancer surgery. TRIAL REGISTRATION NUMBER: NCT01404377.
Authors: Prema Thavaneswaran; Glenda E Rudkin; Rodney D Cooter; Donald G Moyes; Caryn L Perera; Guy J Maddern Journal: Anesth Analg Date: 2010-05-06 Impact factor: 5.108
Authors: Judy C Boughey; Farzin Goravanchi; Ronald N Parris; Spencer S Kee; John C Frenzel; Kelly K Hunt; Frederick C Ames; Henry M Kuerer; Anthony Lucci Journal: Breast J Date: 2009-07-13 Impact factor: 2.431
Authors: Judy C Boughey; Farzin Goravanchi; Ronald N Parris; Spencer S Kee; Alicia M Kowalski; John C Frenzel; Isabelle Bedrosian; Funda Meric-Bernstam; Kelly K Hunt; Frederick C Ames; Henry M Kuerer; Anthony Lucci Journal: Am J Surg Date: 2009-05-09 Impact factor: 2.565
Authors: Erica J Weinstein; Jacob L Levene; Marc S Cohen; Doerthe A Andreae; Jerry Y Chao; Matthew Johnson; Charles B Hall; Michael H Andreae Journal: Cochrane Database Syst Rev Date: 2018-06-20
Authors: Esther A C Bouman; Maurice Theunissen; Alfons Gh Kessels; Kristien Bmi Keymeulen; Elbert Aj Joosten; Marco Ae Marcus; Wolfgang F Buhre; Hans-Fritz Gramke Journal: Springerplus Date: 2014-09-11
Authors: Erica J Weinstein; Jacob L Levene; Marc S Cohen; Doerthe A Andreae; Jerry Y Chao; Matthew Johnson; Charles B Hall; Michael H Andreae Journal: Cochrane Database Syst Rev Date: 2018-04-25
Authors: Giuseppe Paladini; Stefano Di Carlo; Giuseppe Musella; Emiliano Petrucci; Paolo Scimia; Andrea Ambrosoli; Vincenza Cofini; Pierfrancesco Fusco Journal: J Pain Res Date: 2020-01-31 Impact factor: 3.133