| Literature DB >> 22108199 |
Zijian Li1, Xue Chen, Lili Li, Sufang Liu, Lifang Yang, Xiaoqian Ma, Min Tang, Ann M Bode, Zigang Dong, Lunquan Sun, Ya Cao.
Abstract
miRNAs (microRNAs) are a class of non-coding small RNAs. The Epstein-Barr-virus (EBV) encoded miR-BHRF1-1 is barely expressed in most nasopharyngeal carcinoma (NPC) cells with EBV latent infection. Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle. The data further suggested that the miR-BHRF1-1-potentiated induction of EBV lytic replication was accompanied by inhibiting p53 expression. Our results demonstrated that the EBV original pathogen miR-BHRF1-1 is involved in the control of EBV late lytic replication by directly targeting the host p53 gene.Entities:
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Year: 2011 PMID： 22108199 DOI： 10.1016/j.biocel.2011.11.007
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085