Literature DB >> 22106936

Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

Youcai Hu1, John B MacMillan.   

Abstract

Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.

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Year:  2011        PMID： 22106936      PMCID： PMC3237914          DOI： 10.1021/ol202944g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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