| Literature DB >> 22106865 |
Xiaoming Tao1, Wanfang Li, Xin Ma, Xiaoming Li, Weizheng Fan, Xiaomin Xie, Tahar Ayad, Virginie Ratovelomanana-Vidal, Zhaoguo Zhang.
Abstract
Various substituted aryl-pyridyl ketones were hydrogenated in the presence of Ru-XylSunPhos-Daipen bifunctional catalytic system with enantiomeric excesses up to 99.5%. Upon introduction of a readily removable ortho-bromo atom to the phenyl ring, enantiomerically enriched 4-chlorophenylpyridylmethanol was obtained by hydrogenation method with 97.3% ee, which provided an important chiral intermediate for some histamine H(1) antagonists.Entities:
Year: 2011 PMID： 22106865 DOI： 10.1021/jo202204j
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354