L S Illis1. 1. Willow Pond House, Lymore Valley, Hampshire, UK. lee@illis.co.uk
Abstract
STUDY DESIGN: Review. OBJECTIVES: To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site. SETTING: Worldwide. METHODS: A search of publications using 'PubMed' and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator. RESULTS: There is no evidence for CNS regeneration. CONCLUSION: A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
STUDY DESIGN: Review. OBJECTIVES: To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site. SETTING: Worldwide. METHODS: A search of publications using 'PubMed' and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator. RESULTS: There is no evidence for CNS regeneration. CONCLUSION: A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
Authors: Michael A Bonaguidi; Ryan P Stadel; Daniel A Berg; Jiaqi Sun; Guo-li Ming; Hongjun Song Journal: Cold Spring Harb Perspect Biol Date: 2016-04-01 Impact factor: 10.005
Authors: Mrinal Rath; Albert H Vette; Shyamsundar Ramasubramaniam; Kun Li; Joel Burdick; Victor R Edgerton; Yury P Gerasimenko; Dimitry G Sayenko Journal: J Neurotrauma Date: 2018-07-05 Impact factor: 5.269
Authors: Dimitry G Sayenko; Mrinal Rath; Adam R Ferguson; Joel W Burdick; Leif A Havton; V Reggie Edgerton; Yury P Gerasimenko Journal: J Neurotrauma Date: 2018-12-15 Impact factor: 5.269