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Literature DB >> 22103613

From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource.

Ellen M McDonagh¹, Michelle Whirl-Carrillo, Yael Garten, Russ B Altman, Teri E Klein.

Abstract

The mission of the Pharmacogenomics Knowledge Base (PharmGKB; www.pharmgkb.org ) is to collect, encode and disseminate knowledge about the impact of human genetic variations on drug responses. It is an important worldwide resource of clinical pharmacogenomic biomarkers available to all. The PharmGKB website has evolved to highlight our knowledge curation and aggregation over our previous emphasis on collecting primary data. This review summarizes the methods we use to drive this expanded scope of 'Knowledge Acquisition to Clinical Applications', the new features available on our website and our future goals.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Biomarkers

Year: 2011 PMID： 22103613 PMCID： PMC3339046 DOI： 10.2217/bmm.11.94

Source DB: PubMed Journal: Biomark Med ISSN： 1752-0363 Impact factor: 2.851

14 in total

1. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.

Authors: M V Relling; T E Klein
Journal: Clin Pharmacol Ther Date: 2011-01-26 Impact factor: 6.875

Review 2. Recent progress in automatically extracting information from the pharmacogenomic literature.

Authors: Yael Garten; Adrien Coulet; Russ B Altman
Journal: Pharmacogenomics Date: 2010-10 Impact factor: 2.533

3. Translational aspects of genetic factors in the prediction of drug response variability: a case study of warfarin pharmacogenomics in a multi-ethnic cohort from Asia.

Authors: S L Chan; C Suo; S C Lee; B C Goh; K S Chia; Y Y Teo
Journal: Pharmacogenomics J Date: 2011-03-08 Impact factor: 3.550

4. PharmGKB summary: methotrexate pathway.

Authors: Torben S Mikkelsen; Caroline F Thorn; Jun J Yang; Cornelia M Ulrich; Deborah French; Gianluigi Zaza; Henry M Dunnenberger; Sharon Marsh; Howard L McLeod; Kathy Giacomini; Mara L Becker; Roger Gaedigk; James Steven Leeder; Leo Kager; Mary V Relling; William Evans; Teri E Klein; Russ B Altman
Journal: Pharmacogenet Genomics Date: 2011-10 Impact factor: 2.089

Review 5. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing.

Authors: J A Johnson; L Gong; M Whirl-Carrillo; B F Gage; S A Scott; C M Stein; J L Anderson; S E Kimmel; M T M Lee; M Pirmohamed; M Wadelius; T E Klein; R B Altman
Journal: Clin Pharmacol Ther Date: 2011-09-07 Impact factor: 6.875

6. PharmGKB summary: very important pharmacogene information for PTGS2.

Authors: Caroline F Thorn; Tilo Grosser; Teri E Klein; Russ B Altman
Journal: Pharmacogenet Genomics Date: 2011-09 Impact factor: 2.089

7. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Authors: Craig Knox; Vivian Law; Timothy Jewison; Philip Liu; Son Ly; Alex Frolkis; Allison Pon; Kelly Banco; Christine Mak; Vanessa Neveu; Yannick Djoumbou; Roman Eisner; An Chi Guo; David S Wishart
Journal: Nucleic Acids Res Date: 2010-11-08 Impact factor: 16.971

8. The BioPAX community standard for pathway data sharing.

Authors: Emek Demir; Michael P Cary; Suzanne Paley; Ken Fukuda; Christian Lemer; Imre Vastrik; Guanming Wu; Peter D'Eustachio; Carl Schaefer; Joanne Luciano; Frank Schacherer; Irma Martinez-Flores; Zhenjun Hu; Veronica Jimenez-Jacinto; Geeta Joshi-Tope; Kumaran Kandasamy; Alejandra C Lopez-Fuentes; Huaiyu Mi; Elgar Pichler; Igor Rodchenkov; Andrea Splendiani; Sasha Tkachev; Jeremy Zucker; Gopal Gopinath; Harsha Rajasimha; Ranjani Ramakrishnan; Imran Shah; Mustafa Syed; Nadia Anwar; Ozgün Babur; Michael Blinov; Erik Brauner; Dan Corwin; Sylva Donaldson; Frank Gibbons; Robert Goldberg; Peter Hornbeck; Augustin Luna; Peter Murray-Rust; Eric Neumann; Oliver Ruebenacker; Oliver Reubenacker; Matthias Samwald; Martijn van Iersel; Sarala Wimalaratne; Keith Allen; Burk Braun; Michelle Whirl-Carrillo; Kei-Hoi Cheung; Kam Dahlquist; Andrew Finney; Marc Gillespie; Elizabeth Glass; Li Gong; Robin Haw; Michael Honig; Olivier Hubaut; David Kane; Shiva Krupa; Martina Kutmon; Julie Leonard; Debbie Marks; David Merberg; Victoria Petri; Alex Pico; Dean Ravenscroft; Liya Ren; Nigam Shah; Margot Sunshine; Rebecca Tang; Ryan Whaley; Stan Letovksy; Kenneth H Buetow; Andrey Rzhetsky; Vincent Schachter; Bruno S Sobral; Ugur Dogrusoz; Shannon McWeeney; Mirit Aladjem; Ewan Birney; Julio Collado-Vides; Susumu Goto; Michael Hucka; Nicolas Le Novère; Natalia Maltsev; Akhilesh Pandey; Paul Thomas; Edgar Wingender; Peter D Karp; Chris Sander; Gary D Bader
Journal: Nat Biotechnol Date: 2010-09-09 Impact factor: 54.908

9. DrugBank: a comprehensive resource for in silico drug discovery and exploration.

Authors: David S Wishart; Craig Knox; An Chi Guo; Savita Shrivastava; Murtaza Hassanali; Paul Stothard; Zhan Chang; Jennifer Woolsey
Journal: Nucleic Acids Res Date: 2006-01-01 Impact factor: 16.971

10. DrugBank: a knowledgebase for drugs, drug actions and drug targets.

Authors: David S Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali
Journal: Nucleic Acids Res Date: 2007-11-29 Impact factor: 16.971

78 in total

1. A pharmacogenetics service experience for pharmacy students, residents, and fellows.

Authors: Katarzyna Drozda; Yana Labinov; Ruixuan Jiang; Margaret R Thomas; Shan S Wong; Shitalben Patel; Edith A Nutescu; Larisa H Cavallari
Journal: Am J Pharm Educ Date: 2013-10-14 Impact factor: 2.047

2. Mining the pharmacogenomics literature--a survey of the state of the art.

Authors: Udo Hahn; K Bretonnel Cohen; Yael Garten; Nigam H Shah
Journal: Brief Bioinform Date: 2012-07 Impact factor: 11.622

3. Dosage individualization of warfarin using artificial neural networks.

Authors: Mohammad I Saleh; Sameh Alzubiedi
Journal: Mol Diagn Ther Date: 2014-06 Impact factor: 4.074

4. Auto-Generated Physiological Chain Data for an Ontological Framework for Pharmacology and Mechanism of Action to Determine Suspected Drugs in Cases of Dysuria.

Authors: Masayo Hayakawa; Takeshi Imai; Yoshimasa Kawazoe; Kouji Kozaki; Kazuhiko Ohe
Journal: Drug Saf Date: 2019-09 Impact factor: 5.606

5. Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202.

Authors: Daniel H Johnson; Charles Venuto; Marylyn D Ritchie; Gene D Morse; Eric S Daar; Paul J McLaren; David W Haas
Journal: Pharmacogenet Genomics Date: 2014-04 Impact factor: 2.089