PURPOSE: The authors sought to define treatment results according to the different accrual periods and clinical-therapeutic features in a large series of nasopharyngeal cancer (NPC) patients treated in two Italian centres over more than two decades. MATERIALS AND METHODS: A total of 883 patients consecutively treated with radiotherapy between 1977 and 2000 at the Florence (FLO) and Brescia (IRA) Radiation Oncology centres were studied. Five-year overall (OS) and disease-specific (DSS) actuarial survival rates in the different pathological, clinical and therapeutic subgroups were calculated, along with the actuarial local-regional control (LRC) probability. RESULTS: At univariate analysis, survival and local control rates were significantly better in the more recent accrual periods and in the more favourable disease presentations; treatment-related parameters mainly affect LRC. At multivariate analysis, patient- and disease-related factors had a more evident prognostic effect than did therapeutic factors, although dose to the nasopharynx and treatment technique had a marginally significant impact on DSS and OS. CONCLUSIONS: Results of this benchmark study may be useful for understanding the development of new radio-therapy techniques for NPC, such as three-dimensional conformal radiotherapy (3D-CRT) and particularly intensity-modulated radiotherapy (IMRT).
PURPOSE: The authors sought to define treatment results according to the different accrual periods and clinical-therapeutic features in a large series of nasopharyngeal cancer (NPC) patients treated in two Italian centres over more than two decades. MATERIALS AND METHODS: A total of 883 patients consecutively treated with radiotherapy between 1977 and 2000 at the Florence (FLO) and Brescia (IRA) Radiation Oncology centres were studied. Five-year overall (OS) and disease-specific (DSS) actuarial survival rates in the different pathological, clinical and therapeutic subgroups were calculated, along with the actuarial local-regional control (LRC) probability. RESULTS: At univariate analysis, survival and local control rates were significantly better in the more recent accrual periods and in the more favourable disease presentations; treatment-related parameters mainly affect LRC. At multivariate analysis, patient- and disease-related factors had a more evident prognostic effect than did therapeutic factors, although dose to the nasopharynx and treatment technique had a marginally significant impact on DSS and OS. CONCLUSIONS: Results of this benchmark study may be useful for understanding the development of new radio-therapy techniques for NPC, such as three-dimensional conformal radiotherapy (3D-CRT) and particularly intensity-modulated radiotherapy (IMRT).
Authors: Peter M L Teo; Sing Fai Leung; Stewart Y Tung; Benny Zee; Jonathan S T Sham; Anne W M Lee; Wai Hon Lau; Wing Hong Kwan; To Wai Leung; Daniel Chua; Wai Man Sze; Joseph S K Au; Kwok Hung Yu; Sai Ki O; Dora Kwong; Tsz Kok Yau; Stephen C K Law; Wing Kin Sze; Gordon Au; Anthony T C Chan Journal: Radiother Oncol Date: 2006-04-19 Impact factor: 6.280
Authors: G Zini; G Alberti; L Armaroli; E Barbieri; G Di Marzio; G Frezza; S Neri; M Silvano; L Babini Journal: Radiol Med Date: 1989-11 Impact factor: 3.469
Authors: S Tonoli; D Alterio; O Caspiani; A Bacigalupo; F Bunkheila; M Cianciulli; A Merlotti; A Podhradska; M Rampino; D Cante; L Bruschieri; R Gatta; S M Magrini Journal: Strahlenther Onkol Date: 2016-10-19 Impact factor: 3.621