RATIONALE: Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES: This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity. METHODS: The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms. RESULTS: Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable. CONCLUSIONS: The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.
RATIONALE: Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES: This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity. METHODS: The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms. RESULTS: Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable. CONCLUSIONS: The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.
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