RATIONALE: Recent evidence has implicated the opioid system in exaggerated ethanol consumption and impulsivity deficits. The opioid receptor antagonist naltrexone (NTX) has proven efficient in reducing alcohol consumption; however, its role on impulsive behaviour is not fully characterised. OBJECTIVE: The aim of this study was to investigate the effects of NTX on two measures of impulsive behaviour in two inbred mouse strains that differ in ethanol preference and impulsive phenotype. METHODS: Two separate groups of C57BL/6J (B6, n = 24) and DBA2/J (D2, n = 24) male mice were exposed to intermittent ethanol (IEE; 2 g/kg) during early (PND 30-45, IEE_Early) or late (PND 45-60, IEE_Late) adolescence or the respective saline control. The ability of NTX (10 mg/kg) alone, or co-administered with ethanol (0.5 g/kg), to diminish waiting impulsivity in the five-choice serial reaction time task (5-CSRTT), or improve decision-making in a mouse version of the Iowa Gambling Task (mIGT), was examined in adulthood. RESULTS: In the 5-CSRTT, NTX diminished impulsivity in both strains of mice, irrespective of previous ethanol experience. In the mIGT, NTX failed to alter risky decision-making but decreased perseverative responding. CONCLUSIONS: Blocking the actions of endogenous opioids may attenuate waiting impulsivity, in addition to alleviating perseverative responding. In a broader context, μ-opiate antagonism may be of potential interest for impulse-control disorders.
RATIONALE: Recent evidence has implicated the opioid system in exaggerated ethanol consumption and impulsivity deficits. The opioid receptor antagonist naltrexone (NTX) has proven efficient in reducing alcohol consumption; however, its role on impulsive behaviour is not fully characterised. OBJECTIVE: The aim of this study was to investigate the effects of NTX on two measures of impulsive behaviour in two inbred mouse strains that differ in ethanol preference and impulsive phenotype. METHODS: Two separate groups of C57BL/6J (B6, n = 24) and DBA2/J (D2, n = 24) male mice were exposed to intermittent ethanol (IEE; 2 g/kg) during early (PND 30-45, IEE_Early) or late (PND 45-60, IEE_Late) adolescence or the respective saline control. The ability of NTX (10 mg/kg) alone, or co-administered with ethanol (0.5 g/kg), to diminish waiting impulsivity in the five-choice serial reaction time task (5-CSRTT), or improve decision-making in a mouse version of the Iowa Gambling Task (mIGT), was examined in adulthood. RESULTS: In the 5-CSRTT, NTX diminished impulsivity in both strains of mice, irrespective of previous ethanol experience. In the mIGT, NTX failed to alter risky decision-making but decreased perseverative responding. CONCLUSIONS: Blocking the actions of endogenous opioids may attenuate waiting impulsivity, in addition to alleviating perseverative responding. In a broader context, μ-opiate antagonism may be of potential interest for impulse-control disorders.
Authors: Jennifer M Mitchell; Venessa C Tavares; Howard L Fields; Mark D'Esposito; Charlotte A Boettiger Journal: Neuropsychopharmacology Date: 2006-10-18 Impact factor: 7.853
Authors: Liam J Nestor; Louise M Paterson; Anna Murphy; John McGonigle; Csaba Orban; Laurence Reed; Eleanor Taylor; Remy Flechais; Dana Smith; Edward T Bullmore; Karen D Ersche; John Suckling; Rebecca Elliott; Bill Deakin; Ilan Rabiner; Anne Lingford Hughes; Barbara J Sahakian; Trevor W Robbins; David J Nutt Journal: Eur J Neurosci Date: 2018-11-26 Impact factor: 3.386
Authors: Yolanda Peña-Oliver; Fabiana M Carvalho; Sandra Sanchez-Roige; Erin B Quinlan; Tianye Jia; Tom Walker-Tilley; Stuart L Rulten; Frances M G Pearl; Tobias Banaschewski; Gareth J Barker; Arun L W Bokde; Christian Büchel; Patricia J Conrod; Herta Flor; Jürgen Gallinat; Hugh Garavan; Andreas Heinz; Penny Gowland; Marie-Laure Paillere Martinot; Tomáš Paus; Marcella Rietschel; Trevor W Robbins; Michael N Smolka; Gunter Schumann; David N Stephens Journal: Front Genet Date: 2016-04-07 Impact factor: 4.599