Literature DB >> 22085765

Glycyrrhetinic acid protects mice from Staphylococcus aureus pneumonia.

Hong-en Li1, Jia-zhang Qiu, Zhan-qing Yang, Jing Dong, Jian-feng Wang, Ming-jing Luo, Juan Pan, Xiao-han Dai, Yu Zhang, Bai-lin Song, Xu-ming Deng.   

Abstract

In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system.
Copyright © 2011. Published by Elsevier B.V.

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Year:  2011        PMID： 22085765     DOI： 10.1016/j.fitote.2011.10.018

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  8 in total

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Authors:  Jay M Hendricks; Carol Hoffman; David W Pascual; Michele E Hardy
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Authors:  Huaqiao Tang; Gina Porras; Morgan M Brown; Francois Chassagne; James T Lyles; John Bacsa; Alexander R Horswill; Cassandra L Quave
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  8 in total

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