OBJECTIVES: A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance. However, the neural system effects of CACNA1C that mediate the association are not known. In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD. METHODS: A total of 55 European Americans were divided into two groups: a GG group homozygous for the 'G' allele (n = 30) and carriers of the high risk A allele ('A-carrier' group, AA/AG genotypes; n = 25). The subjects participated in both high-resolution structural magnetic resonance imaging (MRI) scans and functional MRI scans during emotional face-processing. Voxel-based morphometry and functional connectivity analyses were performed. RESULTS: Compared to the GG group, the A-carrier group showed significantly increased gray matter volume and reduced functional connectivity within a corticolimbic frontotemporal neural system (p < 0.05, corrected). CONCLUSION: The findings support effects of the rs1006737 variation on the frontotemporal neural system implicated in BD, both in gray matter morphology and in functional connectivity. This suggests that influence of CACNA1C variation on corticolimbic structure and function may be a mechanism contributing to the neural circuitry of BD.
OBJECTIVES: A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance. However, the neural system effects of CACNA1C that mediate the association are not known. In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD. METHODS: A total of 55 European Americans were divided into two groups: a GG group homozygous for the 'G' allele (n = 30) and carriers of the high risk A allele ('A-carrier' group, AA/AG genotypes; n = 25). The subjects participated in both high-resolution structural magnetic resonance imaging (MRI) scans and functional MRI scans during emotional face-processing. Voxel-based morphometry and functional connectivity analyses were performed. RESULTS: Compared to the GG group, the A-carrier group showed significantly increased gray matter volume and reduced functional connectivity within a corticolimbic frontotemporal neural system (p < 0.05, corrected). CONCLUSION: The findings support effects of the rs1006737 variation on the frontotemporal neural system implicated in BD, both in gray matter morphology and in functional connectivity. This suggests that influence of CACNA1C variation on corticolimbic structure and function may be a mechanism contributing to the neural circuitry of BD.
Authors: M Wessa; J Linke; S H Witt; V Nieratschker; C Esslinger; P Kirsch; O Grimm; M G Hennerici; A Gass; A V King; M Rietschel Journal: Mol Psychiatry Date: 2010-03-30 Impact factor: 15.992
Authors: Susanne Erk; Andreas Meyer-Lindenberg; Knut Schnell; Carola Opitz von Boberfeld; Christine Esslinger; Peter Kirsch; Oliver Grimm; Claudia Arnold; Leila Haddad; Stephanie H Witt; Sven Cichon; Markus M Nöthen; Marcella Rietschel; Henrik Walter Journal: Arch Gen Psychiatry Date: 2010-08
Authors: Hilary P Blumberg; Fei Wang; Lara G Chepenik; Jessica H Kalmar; Elliot Kale Edmiston; Ronald S Duman; Joel Gelernter Journal: Biol Psychiatry Date: 2008-08-15 Impact factor: 13.382
Authors: Manuel A R Ferreira; Michael C O'Donovan; Yan A Meng; Ian R Jones; Douglas M Ruderfer; Lisa Jones; Jinbo Fan; George Kirov; Roy H Perlis; Elaine K Green; Jordan W Smoller; Detelina Grozeva; Jennifer Stone; Ivan Nikolov; Kimberly Chambert; Marian L Hamshere; Vishwajit L Nimgaonkar; Valentina Moskvina; Michael E Thase; Sian Caesar; Gary S Sachs; Jennifer Franklin; Katherine Gordon-Smith; Kristin G Ardlie; Stacey B Gabriel; Christine Fraser; Brendan Blumenstiel; Matthew Defelice; Gerome Breen; Michael Gill; Derek W Morris; Amanda Elkin; Walter J Muir; Kevin A McGhee; Richard Williamson; Donald J MacIntyre; Alan W MacLean; Clair David St; Michelle Robinson; Margaret Van Beck; Ana C P Pereira; Radhika Kandaswamy; Andrew McQuillin; David A Collier; Nicholas J Bass; Allan H Young; Jacob Lawrence; I Nicol Ferrier; Adebayo Anjorin; Anne Farmer; David Curtis; Edward M Scolnick; Peter McGuffin; Mark J Daly; Aiden P Corvin; Peter A Holmans; Douglas H Blackwood; Hugh M Gurling; Michael J Owen; Shaun M Purcell; Pamela Sklar; Nick Craddock Journal: Nat Genet Date: 2008-09 Impact factor: 38.330
Authors: Jennifer A Sumner; Margaret A Sheridan; Stacy S Drury; Kyle C Esteves; Kate Walsh; Karestan C Koenen; Katie A McLaughlin Journal: J Child Adolesc Psychopharmacol Date: 2015-09-24 Impact factor: 2.576
Authors: Amit Anand; Daniel L Koller; William B Lawson; Elliot S Gershon; John I Nurnberger Journal: J Affect Disord Date: 2015-03-10 Impact factor: 4.839
Authors: H W Thermenos; S Whitfield-Gabrieli; L J Seidman; G Kuperberg; R J Juelich; S Divatia; C Riley; G A Jabbar; M E Shenton; M Kubicki; T Manschreck; M S Keshavan; L E DeLisi Journal: Schizophr Res Date: 2013-10-28 Impact factor: 4.939
Authors: Frieder M Paulus; Johannes Bedenbender; Sören Krach; Martin Pyka; Axel Krug; Jens Sommer; Miriam Mette; Markus M Nöthen; Stephanie H Witt; Marcella Rietschel; Tilo Kircher; Andreas Jansen Journal: Hum Brain Mapp Date: 2013-02-13 Impact factor: 5.038
Authors: Shambhu Bhat; David T Dao; Chantelle E Terrillion; Michal Arad; Robert J Smith; Nikolai M Soldatov; Todd D Gould Journal: Prog Neurobiol Date: 2012-06-15 Impact factor: 11.685
Authors: Ming Li; Xiong-jian Luo; Mikael Landén; Sarah E Bergen; Christina M Hultman; Xiao Li; Wen Zhang; Yong-Gang Yao; Chen Zhang; Jiewei Liu; Manuel Mattheisen; Sven Cichon; Thomas W Mühleisen; Franziska A Degenhardt; Markus M Nöthen; Thomas G Schulze; Maria Grigoroiu-Serbanescu; Hao Li; Chris K Fuller; Chunhui Chen; Qi Dong; Chuansheng Chen; Stéphane Jamain; Marion Leboyer; Frank Bellivier; Bruno Etain; Jean-Pierre Kahn; Chantal Henry; Martin Preisig; Zoltán Kutalik; Enrique Castelao; Adam Wright; Philip B Mitchell; Janice M Fullerton; Peter R Schofield; Grant W Montgomery; Sarah E Medland; Scott D Gordon; Nicholas G Martin; Marcella Rietschel; Chunyu Liu; Joel E Kleinman; Thomas M Hyde; Daniel R Weinberger; Bing Su Journal: Br J Psychiatry Date: 2015-09-03 Impact factor: 9.319