BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring. METHODS: Seventy-three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992-2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)-2, -8, -9, and -13 was compared with patient characteristics and outcome. RESULTS: Nuclear expression of MMP-13, but not cytoplasmic expression of MMP-2, -8, and -9, was associated with invasion depth (P = 0.017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042). CONCLUSION: Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC.
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring. METHODS: Seventy-three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992-2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)-2, -8, -9, and -13 was compared with patient characteristics and outcome. RESULTS: Nuclear expression of MMP-13, but not cytoplasmic expression of MMP-2, -8, and -9, was associated with invasion depth (P = 0.017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042). CONCLUSION: Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC.
Authors: Ilkka Heikkinen; Alhadi Almangush; Jaana Hagström; Ibrahim O Bello; Joonas H Kauppila; Laura K Mäkinen; Caj Haglund; Pentti Nieminen; Tuula Salo; Ilmo Leivo Journal: Eur Arch Otorhinolaryngol Date: 2016-04-18 Impact factor: 2.503
Authors: Vui King Vincent-Chong; Iman Salahshourifar; Lee Peng Karen-Ng; Ming Yhong Siow; Thomas George Kallarakkal; Anand Ramanathan; Yi-Hsin Yang; Goot Heah Khor; Zainal Ariff Abdul Rahman; Siti Mazlipah Ismail; Narayanan Prepageran; Wan Mahadzir Wan Mustafa; Mannil Thomas Abraham; Keng Kiong Tay; Sok Ching Cheong; Rosnah Binti Zain Journal: ScientificWorldJournal Date: 2014-10-23
Authors: Pirjo Åström; Krista Juurikka; Elin S Hadler-Olsen; Gunbjørg Svineng; Nilva K Cervigne; Ricardo D Coletta; Juha Risteli; Joonas H Kauppila; Sini Skarp; Samuel Kuttner; Ana Oteiza; Meeri Sutinen; Tuula Salo Journal: Br J Cancer Date: 2017-08-03 Impact factor: 7.640