| Literature DB >> 27091335 |
Ilkka Heikkinen1,2, Alhadi Almangush1,2,3, Jaana Hagström1,4, Ibrahim O Bello5, Joonas H Kauppila6,7, Laura K Mäkinen8, Caj Haglund4,9, Pentti Nieminen10, Tuula Salo2,11,12,13, Ilmo Leivo14,15.
Abstract
The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this study. Expression of securin in OTSCC was studied by immunohistochemistry of tissue microarrays (52 cases) and routine tumor sections (41 cases). Securin overexpression is significantly associated with higher tumor grade (P = 0.03). Overexpression of securin was observed more frequently in advanced stages of OTSCC than in earlier stages but the difference was not statistically significant. These findings suggest that overexpression of securin in OTSCC may be important during progression of this cancer. No significant association was found between securin expression and the prognosis of OTSCC.Entities:
Keywords: Expression; Oral tongue squamous cell carcinoma; Prognosis; Securin
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Year: 2016 PMID： 27091335 DOI： 10.1007/s00405-016-3964-y
Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503