| Literature DB >> 22082460 |
Ananth Narayanan1, Catherine A White, Sanjida S Saklayen, Amir Abduljalil, Petra Schmalbrock, Tom H Pepper, Brad N Lander, David Q Beversdorf.
Abstract
Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in acute cocaine withdrawal. Eight subjects in acute cocaine withdrawal were compared to controls for connectivity in language areas while performing a task involving categorization of words according to semantic and phonological relatedness. Acute withdrawal subjects had significantly less overall connectivity during semantic relatedness, and a trend towards less connectivity during phonological relatedness. Of potential future interest is whether this might serve as an imaging marker for treatment in patients.Entities:
Mesh:
Year: 2011 PMID: 22082460 PMCID: PMC3288306 DOI: 10.1080/13554794.2011.627341
Source DB: PubMed Journal: Neurocase ISSN: 1355-4794 Impact factor: 0.881