BACKGROUND: Quality of life (QoL) has become a major outcome in the treatment of patients with cancer. This study is aimed at examining the impact of chemotherapy-induced nausea and vomiting on QoL of patients with gynecologic cancer in Indonesia. METHODS: Chemotherapy-naive patients with gynecologic cancer, who were treated with cisplatin at a dosage 50 mg/m or higher as monotherapy or as part of combination chemotherapy regimens, were recruited in the Oncology Department, Dr. Sardjito Hospital, Yogyakarta, Indonesia. Quality of life was assessed by using the Indonesian version of the European Organization for Research and Treatment for Cancer of Quality of Life Questionnaire and Short Form-36, administered immediately before and on day 5 after chemotherapy administration. Patients used a daily diary to record nausea and vomiting during 5 days after chemotherapy. RESULTS: Most (74.9%) of the 179 patients experienced delayed emesis during the 5 days after chemotherapy despite prophylactic use of antiemetics. The delayed nausea and emesis caused significant negative impact on patients' QoL. Nausea in the delayed phase caused negative effects on patients' QoL. CONCLUSIONS: Patients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients' nausea and vomiting after chemotherapy interferes with patients' QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics.
BACKGROUND: Quality of life (QoL) has become a major outcome in the treatment of patients with cancer. This study is aimed at examining the impact of chemotherapy-induced nausea and vomiting on QoL of patients with gynecologic cancer in Indonesia. METHODS: Chemotherapy-naive patients with gynecologic cancer, who were treated with cisplatin at a dosage 50 mg/m or higher as monotherapy or as part of combination chemotherapy regimens, were recruited in the Oncology Department, Dr. Sardjito Hospital, Yogyakarta, Indonesia. Quality of life was assessed by using the Indonesian version of the European Organization for Research and Treatment for Cancer of Quality of Life Questionnaire and Short Form-36, administered immediately before and on day 5 after chemotherapy administration. Patients used a daily diary to record nausea and vomiting during 5 days after chemotherapy. RESULTS: Most (74.9%) of the 179 patients experienced delayed emesis during the 5 days after chemotherapy despite prophylactic use of antiemetics. The delayed nausea and emesis caused significant negative impact on patients' QoL. Nausea in the delayed phase caused negative effects on patients' QoL. CONCLUSIONS:Patients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients' nausea and vomiting after chemotherapy interferes with patients' QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics.
Authors: Ruey Kuen Hsieh; Alexandre Chan; Hoon-Kyo Kim; Shiying Yu; Jong Gwang Kim; Myung-Ah Lee; Johan Dalén; Hun Jung; Yan Ping Liu; Thomas A Burke; Dorothy M K Keefe Journal: Support Care Cancer Date: 2014-08-14 Impact factor: 3.603
Authors: Hoon-Kyo Kim; RueyKuen Hsieh; Alexandre Chan; Shiying Yu; Baohui Han; Yunong Gao; Ana Baños; Xiaoyan Ying; Thomas A Burke; Dorothy M K Keefe Journal: Support Care Cancer Date: 2014-08-21 Impact factor: 3.603
Authors: Dorothy M K Keefe; Alexandre Chan; Hoon-Kyo Kim; Ruey Kuen Hsieh; Shiying Yu; Yachuan Wang; Rebecca J Nicholls; Thomas A Burke Journal: Support Care Cancer Date: 2014-08-13 Impact factor: 3.603
Authors: Yolanda Escobar; Gerardo Cajaraville; Juan Antonio Virizuela; Rosa Álvarez; Andrés Muñoz; Olatz Olariaga; María José Tamés; Begoña Muros; María Jose Lecumberri; Jaime Feliu; Purificación Martínez; Juan Carlos Adansa; María José Martínez; Rafael López; Ana Blasco; Pere Gascón; Virginia Calvo; Pablo Luna; Joaquín Montalar; Patricia Del Barrio; María Victoria Tornamira Journal: Support Care Cancer Date: 2015-06-17 Impact factor: 3.603