OBJECTIVE: To explore the association between polymorphism of the human leukocyte antigen G (HLA-G) and susceptibility of esophageal carcinoma (EC) in Kazakh and Han nationality in Xinjiang. METHODS: The 14 bp deletion/insertion (rs16375) and 0105N (rs41557518) of HLA-G genotyping were determined by PCR and PCR-RFLP, respectively in 239 patients and 467 controls. RESULTS: There was a 2.69-fold (P(c) = 0.04, 95% CI: 1.30-5.55) increased risk of developing EC in individuals with the -14 bp/-14 bp genotype (rs16375) compared with those carrying +14 bp/+14 bp genotype in Kazakh after Bonferroni correction, there was no association of 0105N (rs41557518) both in Kazak and Han population. And there was a 2.82-fold (P(c) = 0.04, 95% CI: 1.32-6.04) increased risk of developing EC in individuals with -14 bp/-14 bp and C/C genotypes compared with those who had +14 bp/+14 bp and C/C genotypes in Kazakh. CONCLUSIONS: The study demonstrates that EC is associated with polymorphism of HLA-G14 bp in Chinese Kazak population. The 14 bp deletion/insertion of HLA-G gene may play a role in EC susceptibility of Kazakh.
OBJECTIVE: To explore the association between polymorphism of the human leukocyte antigen G (HLA-G) and susceptibility of esophageal carcinoma (EC) in Kazakh and Han nationality in Xinjiang. METHODS: The 14 bp deletion/insertion (rs16375) and 0105N (rs41557518) of HLA-G genotyping were determined by PCR and PCR-RFLP, respectively in 239 patients and 467 controls. RESULTS: There was a 2.69-fold (P(c) = 0.04, 95% CI: 1.30-5.55) increased risk of developing EC in individuals with the -14 bp/-14 bp genotype (rs16375) compared with those carrying +14 bp/+14 bp genotype in Kazakh after Bonferroni correction, there was no association of 0105N (rs41557518) both in Kazak and Han population. And there was a 2.82-fold (P(c) = 0.04, 95% CI: 1.32-6.04) increased risk of developing EC in individuals with -14 bp/-14 bp and C/C genotypes compared with those who had +14 bp/+14 bp and C/C genotypes in Kazakh. CONCLUSIONS: The study demonstrates that EC is associated with polymorphism of HLA-G14 bp in Chinese Kazak population. The 14 bp deletion/insertion of HLA-G gene may play a role in EC susceptibility of Kazakh.
Authors: Fabrício C Dias; Erick C Castelli; Cristhianna V A Collares; Philippe Moreau; Eduardo A Donadi Journal: Front Immunol Date: 2015-02-02 Impact factor: 7.561
Authors: Erick C Castelli; Jaqueline Ramalho; Iane O P Porto; Thálitta H A Lima; Leandro P Felício; Audrey Sabbagh; Eduardo A Donadi; Celso T Mendes-Junior Journal: Front Immunol Date: 2014-10-06 Impact factor: 7.561
Authors: José Manuel Martín-Villa; Christian Vaquero-Yuste; Marta Molina-Alejandre; Ignacio Juarez; Fabio Suárez-Trujillo; Adrián López-Nares; José Palacio-Gruber; Luis Barrera-Gutiérrez; Eduardo Fernández-Cruz; Carmen Rodríguez-Sainz; Antonio Arnaiz-Villena Journal: Front Immunol Date: 2022-01-27 Impact factor: 7.561