| Literature DB >> 22079466 |
Lian Shu Piao1, Wonhee Hur, Taek-Kyun Kim, Sung Woo Hong, Sung Woo Kim, Jung Eun Choi, Pil Soo Sung, Myeong Joon Song, Byeong-Chel Lee, Daehee Hwang, Seung Kew Yoon.
Abstract
CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers. In the present study, CD133-expressing liver cancer cells following radiation exposure showed higher activation of MAPK/PI3K signaling pathway and reduction in reactive oxygen species levels compared to CD133- cells. The in vivo study with a xenograft model showed increased tumor formation in irradiated CD133+ cell-injected nude mice compared to the CD133- group, suggesting that CD133 contributes to radioresistance in HCC. Therefore, CD133-expressing liver cancer cells have anti-apoptotic and radioresistance properties that may be useful to improve anti-cancer treatments, including chemotherapy/radiotherapy of HCC. CrownEntities:
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Year: 2011 PMID： 22079466 DOI： 10.1016/j.canlet.2011.10.012
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679