| Literature DB >> 28428278 |
Nidhi Jariwala1, Devaraja Rajasekaran1, Rachel G Mendoza1, Xue-Ning Shen1, Ayesha Siddiq1, Maaged A Akiel1, Chadia L Robertson1, Mark A Subler1, Jolene J Windle1, Paul B Fisher1,2,3, Arun J Sanyal4, Devanand Sarkar5,2,3.
Abstract
SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). In this study, we show that hepatocyte-specific SND1 transgenic mice (Alb/SND1 mice) develop spontaneous HCC with partial penetrance and exhibit more highly aggressive HCC induced by chemical carcinogenesis. Livers from Alb/SND1 mice exhibited a relative increase in inflammatory markers and spheroid-generating tumor-initiating cells (TIC). Mechanistic investigations defined roles for Akt and NF-κB signaling pathways in promoting TIC formation in Alb/SND1 mice. In human xenograft models of subcutaneous or orthotopic HCC, administration of the selective SND1 inhibitor 3', 5'-deoxythymidine bisphosphate (pdTp), inhibited tumor formation without effects on body weight or liver function. Our work establishes an oncogenic role for SND1 in promoting TIC formation and highlights pdTp as a highly selective SND1 inhibitor as a candidate therapeutic lead to treat advanced HCC. Cancer Res; 77(12); 3306-16. ©2017 AACR. ©2017 American Association for Cancer Research.Entities:
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Year: 2017 PMID： 28428278 PMCID： PMC5488274 DOI： 10.1158/0008-5472.CAN-17-0298
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701