Literature DB >> 22078126

The end of gonad-centric sex determination in mammals.

Arthur P Arnold1.   

Abstract

The 20th-century theory of mammalian sex determination states that the embryo is sexually indifferent until the differentiation of gonads, after which sex differences in phenotype are caused by the differential effects of gonadal hormones. However, this theory is inadequate because some sex differences precede differentiation of the gonads and/or are determined by non-gonadal effects of the sexual inequality in the number and type of sex chromosomes. In this article, I propose a general theory of sex determination, which recognizes multiple parallel primary sex-determining pathways initiated by genes or factors encoded by the sex chromosomes. The separate sex-specific pathways interact to synergize with or antagonize each other, enhancing or reducing sex differences in phenotype.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22078126      PMCID： PMC3268825          DOI： 10.1016/j.tig.2011.10.004

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  71 in total

1.  Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch.

Authors:  Robert J Agate; William Grisham; Juli Wade; Suzanne Mann; John Wingfield; Carolyn Schanen; Aarno Palotie; Arthur P Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-02       Impact factor: 11.205

2.  Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster.

Authors:  Pan-Pan Jiang; Daniel L Hartl; Bernardo Lemos
Journal:  Genetics       Date:  2010-06-15       Impact factor: 4.562

3.  Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.

Authors:  Atila van Nas; Debraj Guhathakurta; Susanna S Wang; Nadir Yehya; Steve Horvath; Bin Zhang; Leslie Ingram-Drake; Gautam Chaudhuri; Eric E Schadt; Thomas A Drake; Arthur P Arnold; Aldons J Lusis
Journal:  Endocrinology       Date:  2008-10-30       Impact factor: 4.736

Review 4.  The delicate balance between male and female sex determining pathways: potential for disruption of early steps in sexual development.

Authors:  P Koopman
Journal:  Int J Androl       Date:  2009-10-21

Review 5.  SRY and sex determination in mammals.

Authors:  P N Goodfellow; R Lovell-Badge
Journal:  Annu Rev Genet       Date:  1993       Impact factor: 16.830

Review 6.  FOXL2 versus SOX9: a lifelong "battle of the sexes".

Authors:  Reiner A Veitia
Journal:  Bioessays       Date:  2010-05       Impact factor: 4.345

7.  Epigenetic differences between male and female bovine blastocysts produced in vitro.

Authors:  P Bermejo-Alvarez; D Rizos; D Rath; P Lonergan; A Gutierrez-Adan
Journal:  Physiol Genomics       Date:  2007-11-06       Impact factor: 3.107

8.  Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes.

Authors:  Xuqi Chen; Rebecca Watkins; Emmanuele Delot; Ramune Reliene; Robert H Schiestl; Paul S Burgoyne; Arthur P Arnold
Journal:  Dev Neurobiol       Date:  2008-02-01       Impact factor: 3.964

Review 9.  What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?

Authors:  Arthur P Arnold; Xuqi Chen
Journal:  Front Neuroendocrinol       Date:  2008-11-11       Impact factor: 8.606

10.  Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice.

Authors:  William Davies; Anthony Isles; Rachel Smith; Delicia Karunadasa; Doreen Burrmann; Trevor Humby; Obah Ojarikre; Carol Biggin; David Skuse; Paul Burgoyne; Lawrence Wilkinson
Journal:  Nat Genet       Date:  2005-05-22       Impact factor: 38.330
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  79 in total

Review 1.  Understanding the sexome: measuring and reporting sex differences in gene systems.

Authors:  Arthur P Arnold; Aldons J Lusis
Journal:  Endocrinology       Date:  2012-03-20       Impact factor: 4.736

2.  Integrative analysis of methylome and transcriptome in human blood identifies extensive sex- and immune cell-specific differentially methylated regions.

Authors:  Shimrat Mamrut; Nili Avidan; Elsebeth Staun-Ram; Elizabeta Ginzburg; Frederique Truffault; Sonia Berrih-Aknin; Ariel Miller
Journal:  Epigenetics       Date:  2015       Impact factor: 4.528

Review 3.  Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.

Authors:  Nancy G Forger; J Alex Strahan; Alexandra Castillo-Ruiz
Journal:  Front Neuroendocrinol       Date:  2016-01-11       Impact factor: 8.606

Review 4.  Epigenetic mechanisms in sexual differentiation of the brain and behaviour.

Authors:  Nancy G Forger
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-02-01       Impact factor: 6.237

5.  The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two.

Authors:  Jingyuan Li; Xuqi Chen; Rebecca McClusky; Maureen Ruiz-Sundstrom; Yuichiro Itoh; Soban Umar; Arthur P Arnold; Mansoureh Eghbali
Journal:  Cardiovasc Res       Date:  2014-03-19       Impact factor: 10.787

Review 6.  Sex differences in circadian timing systems: implications for disease.

Authors:  Matthew Bailey; Rae Silver
Journal:  Front Neuroendocrinol       Date:  2013-11-25       Impact factor: 8.606

7.  X chromosome regulation of autosomal gene expression in bovine blastocysts.

Authors:  Yuichiro Itoh; Arthur P Arnold
Journal:  Chromosoma       Date:  2014-05-13       Impact factor: 4.316

8.  The XX Sex Chromosome Complement is Required in Male and Female Mice for Enhancement of Immunity Induced by Exposure to 3,4-Dichloropropionanilide.

Authors:  Ida Holásková; Jennifer Franko; Robert L Goodman; Arthur P Arnold; Rosana Schafer
Journal:  Am J Reprod Immunol       Date:  2015-03-12       Impact factor: 3.886

Review 9.  Surprising origins of sex differences in the brain.

Authors:  Margaret M McCarthy; Lindsay A Pickett; Jonathan W VanRyzin; Katherine E Kight
Journal:  Horm Behav       Date:  2015-04-25       Impact factor: 3.587

Review 10.  Chromosome Y genetic variants: impact in animal models and on human disease.

Authors:  J W Prokop; C F Deschepper
Journal:  Physiol Genomics       Date:  2015-08-18       Impact factor: 3.107
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